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gpsm2l G protein signaling modulator 2, like [ Danio rerio (zebrafish) ]

Gene ID: 449665, updated on 9-Dec-2024

Summary

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Official Symbol
gpsm2lprovided by ZNC
Official Full Name
G protein signaling modulator 2, likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-223
See related
Ensembl:ENSDARG00000102026 AllianceGenome:ZFIN:ZDB-GENE-041010-223
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Pinsb; zgc:92571
Summary
Predicted to enable G-protein alpha-subunit binding activity and GDP-dissociation inhibitor activity. Predicted to be involved in establishment of mitotic spindle orientation. Predicted to be located in membrane. Predicted to be active in cell cortex. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See gpsm2l in Genome Data Viewer
Location:
chromosome: 23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (40133136..40186944)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (40345648..40392888, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene FYVE and coiled-coil domain autophagy adaptor 1a Neighboring gene FYVE and coiled-coil domain-containing protein 1-like Neighboring gene growth hormone releasing hormone receptor, like Neighboring gene transglutaminase 1 like 2 Neighboring gene transglutaminase 1-like 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  3. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G protein signaling modulator 2, like
Names
G-protein signalling modulator 2, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005936.1 → NP_001005936.1  G protein signaling modulator 2, like

    See identical proteins and their annotated locations for NP_001005936.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083520
    UniProtKB/TrEMBL
    A0A0G2L0Z7, A0A8N7XJC8, Q283H5, Q5XIZ8
    Related
    ENSDARP00000138404.2, ENSDART00000157616.2
    Conserved Domains (7) summary
    smart00028
    Location:45 → 72
    TPR; Tetratricopeptide repeats
    sd00006
    Location:223 → 250
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:223 → 254
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:485 → 506
    GoLoco; GoLoco motif
    pfam13176
    Location:264 → 298
    TPR_7; Tetratricopeptide repeat
    pfam13414
    Location:6 → 72
    TPR_11; TPR repeat
    pfam13424
    Location:183 → 254
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    40133136..40186944
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469788.2 → XP_021325463.1  G protein signaling modulator 2, like isoform X2

    UniProtKB/TrEMBL
    A0A2R8Q6P4, A0A8M9PF08
    Related
    ENSDARP00000148765.1, ENSDART00000185376.1
    Conserved Domains (4) summary
    COG0457
    Location:63 → 316
    TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
    sd00006
    Location:240 → 267
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:502 → 523
    GoLoco; GoLoco motif
    pfam13424
    Location:283 → 351
    TPR_12; Tetratricopeptide repeat

  2. XM_068216739.1 → XP_068072840.1  G protein signaling modulator 2, like isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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