U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eip93F Ecdysone-induced protein 93F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44936, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Eip93Fprovided by FlyBase
Official Full Name
Ecdysone-induced protein 93Fprovided by FlyBase
Primary source
FLYBASE:FBgn0264490
Locus tag
Dmel_CG18389
See related
AllianceGenome:FB:FBgn0264490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO02059370.58; CG18389; Dmel\CG18389; E93; Eip93; eip93f; eip93F; Eip93f; l(3)93; l(3)ry93; lincRNA.833; psg11
Summary
Predicted to enable DNA binding activity. Involved in cellular response to hypoxia. Located in nucleus. Is expressed in several structures, including adult antennal olfactory receptor neurons; central nervous system; midgut; organism subdivision; and salivary gland. Orthologous to human LCOR (ligand dependent nuclear receptor corepressor) and LCORL (ligand dependent nuclear receptor corepressor like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Eip93F in Genome Data Viewer
Location:
93F14-93F14; 3-73 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21949114..22014539)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17774836..17840261)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Quiescin sulfhydryl oxidase 3 Neighboring gene Quiescin sulfhydryl oxidase 2 Neighboring gene Testicular haploid expressed gene Neighboring gene Isocitrate dehydrogenase 3b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuronal E93 is required for adaptation to adult metabolism and behavior. Yip C, et al. Mol Metab, 2024 Jun. PMID 38621602, Free PMC Article
  2. The appearance of cytoplasmic cytochrome C precedes apoptosis during Drosophila salivary gland degradation. Long S, et al. Insect Sci, 2024 Feb. PMID 37370257
  3. Increased chromatin accessibility promotes the evolution of a transcriptional silencer in Drosophila. Ling L, et al. Sci Adv, 2023 Feb 17. PMID 36800429, Free PMC Article
  4. Mblk-1 Transcription Factor Family: Its Roles in Various Animals and Regulation by NOL4 Splice Variants in Mammals. Takayanagi-Kiya S, et al. Int J Mol Sci, 2017 Jan 25. PMID 28125049, Free PMC Article
  5. Mutants for Drosophila Isocitrate Dehydrogenase 3b Are Defective in Mitochondrial Function and Larval Cell Death. Duncan DM, et al. G3 (Bethesda), 2017 Mar 10. PMID 28104670, Free PMC Article

See all (168) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuronal E93 is required for adaptation to adult metabolism and behavior.
    Title: Neuronal E93 is required for adaptation to adult metabolism and behavior.
  2. E93 promotes transcription of RHG genes to initiate apoptosis during Drosophila salivary gland metamorphosis.
    Title: E93 promotes transcription of RHG genes to initiate apoptosis during Drosophila salivary gland metamorphosis.
  3. Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.
    Title: Drosophila E93 promotes adult development and suppresses larval responses to ecdysone during metamorphosis.
  4. Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
    Title: Transcriptome profiling identifies multistep regulation through E93, Forkhead and Ecdysone Oxidase in survival of Malpighian tubules during metamorphosis in Drosophila.
  5. Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.
    Title: Expression of E93 provides an instructive cue to control dynamic enhancer activity and chromatin accessibility during development.
  6. Wing-specific knockdown of the E93 gene in Drosophila impedes wing development.
    Title: Transcription factor E93 regulates wing development by directly promoting Dpp signaling in Drosophila.
  7. This study identified E93, a steroid-hormone-induced transcription factor that downregulates phosphatidylinositol 3-kinase (PI3K) levels to activate autophagy for elimination of mushroom body (MB) neuroblasts.
    Title: E93 Integrates Neuroblast Intrinsic State with Developmental Time to Terminate MB Neurogenesis via Autophagy.
  8. Autophagy and caspase activity are induced by 20E and predominantly transduced by E93 in the remodeling fat body of Drosophila.
    Title: E93 predominantly transduces 20-hydroxyecdysone signaling to induce autophagy and caspase activity in Drosophila fat body.
  9. Here, we show that the transcription factor E93 is the key determinant that promotes adult metamorphosis in both hemimetabolous and holometabolous insects, thus acting as the universal adult specifier.
    Title: Transcription factor E93 specifies adult metamorphosis in hemimetabolous and holometabolous insects.
  10. E93 likely controls the responsiveness of many other target genes because it is required broadly for patterning during metamorphosis.
    Title: Control of target gene specificity during metamorphosis by the steroid response gene E93.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
Ecdysone-induced protein 93F
Names
CG18389-PA
CG18389-PB
CG18389-PC
E3
Eip93F-PA
Eip93F-PB
Eip93F-PC
lethal (3) ry93

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    21949114..22014539
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001104395.2 → NP_001097865.1  Ecdysone-induced protein 93F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097865.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7YU18
    Conserved Domains (1) summary
    pfam05225
    Location:794 → 839
    HTH_psq; helix-turn-helix, Psq domain

  2. NM_143745.3 → NP_652002.2  Ecdysone-induced protein 93F, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652002.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VD60
    Related
    FBpp0083567
    Conserved Domains (1) summary
    pfam05225
    Location:771 → 816
    HTH_psq; helix-turn-helix, Psq domain

  3. NM_001275888.1 → NP_001262817.1  Ecdysone-induced protein 93F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHV1
    Conserved Domains (1) summary
    pfam05225
    Location:771 → 816
    HTH_psq; helix-turn-helix, Psq domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHV1 A0A0B4KHV1
Q24079 Q24079
Q7YU18 Q7YU18
Q9VD60 Q9VD60

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools