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MT1E metallothionein 1E [ Homo sapiens (human) ]

Gene ID: 4493, updated on 27-Nov-2024

Summary

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Official Symbol
MT1Eprovided by HGNC
Official Full Name
metallothionein 1Eprovided by HGNC
Primary source
HGNC:HGNC:7397
See related
Ensembl:ENSG00000169715 MIM:156351; AllianceGenome:HGNC:7397
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MT1; MTD; MT-1E; MT-IE
Summary
Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver (RPKM 106.4), small intestine (RPKM 103.9) and 20 other tissues See more
Orthologs
all
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Genomic context

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See MT1E in Genome Data Viewer
Location:
16q13
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (56625781..56627112)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (62420746..62422077)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (56659693..56661024)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7510 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7511 Neighboring gene metallothionein 2A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:56651076-56651609 Neighboring gene metallothionein 1L (pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:56659379-56659915 Neighboring gene metallothionein 1M Neighboring gene metallothionein 1J, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population. Zou X, et al. Diabetes Care, 2023 Dec 1. PMID 37878528
  2. Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma. Liu Q, et al. Pathol Res Pract, 2020 Nov. PMID 32956919
  3. Identification and spatial analysis of metallothioneins expressed by the adult human lens. Oppermann B, et al. Invest Ophthalmol Vis Sci, 2001 Jan. PMID 11133866, Free PMC Article
  4. Interleukin-1 beta-mediated metallothionein induction and cytoprotection against cadmium and cis-diamminedichloroplatinum. Kondo Y, et al. J Pharmacol Exp Ther, 1994 Sep. PMID 7932184
  5. Activation of metallothioneins and alpha-crystallin/sHSPs in human lens epithelial cells by specific metals and the metal content of aging clear human lenses. Hawse JR, et al. Invest Ophthalmol Vis Sci, 2003 Feb. PMID 12556398, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
    Title: Rare Variant in Metallothionein 1E Increases the Risk of Type 2 Diabetes in a Chinese Population.
  2. Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
    Title: Identification of MT1E as a novel tumor suppressor in hepatocellular carcinoma.
  3. Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
    Title: Metallothionein Genes are Highly Expressed in Malignant Astrocytomas and Associated with Patient Survival.
  4. In clear cell renal cell carcinoma (RCC) MT1E, MT1G and MT1M expression was higher than that noted in other histological tumor subtypes (all P<0.0500). In addition, some associations were observed between metabolic syndromerelated clinical parameters and promoter methylation or gene expression
    Title: DNA methylation of metallothionein genes is associated with the clinical features of renal cell carcinoma.
  5. Forced MT1E expression rescues both hypersensitivity of CDKAL1 mutant cells to glycolipotoxicity and pancreatic beta-cell dysfunction in vitro and in vivo.
    Title: Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E.
  6. MT1E can enhance the migration and invasion of human glioma cells by inducing MMP-9 inactivation via the upregulation of NF-kappaB p50.
    Title: Role of metallothionein 1E in the migration and invasion of human glioma cell lines.
  7. Our results reveal that menopause influences the adipose tissue expression of many genes, especially of neurexin 3, metallothionein 1E, and keratyn 7, which are associated with the alteration of several key biological processes.
    Title: Profile of adipose tissue gene expression in premenopausal and postmenopausal women: site-specific differences.
  8. MT1E is a potential tumour suppressor gene, whose loss may promote resistance to apoptosis-inducing therapies.
    Title: Metallothionein 1E is methylated in malignant melanoma and increases sensitivity to cisplatin-induced apoptosis.
  9. Increases in MT gene expression and intracellular zinc levels may contribute directly to maintenance of an immune-activated monocyte by mediating an increased resistance to apoptosis during active HIV-1 viremia.
    Title: Increased metallothionein gene expression, zinc, and zinc-dependent resistance to apoptosis in circulating monocytes during HIV viremia.
  10. High frequency of hypermethylation of MT-1E was found in endometrial carcinomas.
    Title: Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in cellular response to cadmium ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to cadmium ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to zinc ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to zinc ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in detoxification of copper ion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular zinc ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of growth ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metallothionein-1E
Names
metallothionein 1E (functional)
metallothionein D
metallothionein-IE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363555.2 → NP_001350484.1  metallothionein-1E isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF495759, BC131609
    Consensus CDS
    CCDS86530.1
    Related
    ENSP00000328137.6, ENST00000330439.7
    Conserved Domains (1) summary
    cl19543
    Location:4 → 35
    Metallothio; Metallothionein

  2. NM_175617.4 → NP_783316.2  metallothionein-1E isoform 2

    See identical proteins and their annotated locations for NP_783316.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses alternate splice sites in the 3' coding region compared to variant 1, resulting in a frameshift. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC009699
    Consensus CDS
    CCDS10764.2
    UniProtKB/Swiss-Prot
    A2RRF7, P04732, Q86YX4, Q8TD51
    Related
    ENSP00000307706.5, ENST00000306061.10
    Conserved Domains (1) summary
    pfam00131
    Location:4 → 61
    Metallothio; Metallothionein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    56625781..56627112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    62420746..62422077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04732.1 GenPept UniProtKB/Swiss-Prot:P04732

Gene LinkOut

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