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Prim2 DNA primase subunit 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44915, updated on 9-Dec-2024

Summary

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Official Symbol
Prim2provided by FlyBase
Official Full Name
DNA primase subunit 2provided by FlyBase
Primary source
FLYBASE:FBgn0259676
Locus tag
Dmel_CG5553
See related
AllianceGenome:FB:FBgn0259676
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM13640; CG5553; Dmel\CG5553; Dmpol alpha; DNA polalpha; DNApol-alpha60; DNAprim; DNAprimase; GM13640; l(3)77ABe; l(3)j10B2; Pol; pol alpha; polalpha; Polalpha 60 kDa; PRI2; S(faf)240
Summary
Involved in DNA replication, synthesis of primer; compound eye morphogenesis; and mitotic cell cycle. Part of alpha DNA polymerase:primase complex. Orthologous to human PRIM2 (DNA primase subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Prim2 in Genome Data Viewer
Location:
77B6-77B6; 3-47 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20359833..20361585, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20352933..20354685, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene kin17 Neighboring gene uncharacterized protein Neighboring gene Toll-9 Neighboring gene inturned

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and characterisation of the gene for the large subunit of the DNA primase from Drosophila melanogaster. Huikeshoven H, et al. Biochim Biophys Acta, 1999 Jun 9. PMID 10366721
  2. Joint effects of natural selection and recombination on gene flow between Drosophila ananassae populations. Chen Y, et al. Genetics, 2000 Jul. PMID 10880480, Free PMC Article
  3. A high molecular weight DNA polymerase from Drosophila melanogaster embryos. Purification, structure, and partial characterization. Banks GR, et al. J Biol Chem, 1979 Oct 10. PMID 114515
  4. Synthesis by the DNA primase of Drosophila melanogaster of a primer with a unique chain length. Conaway RC, et al. Proc Natl Acad Sci U S A, 1982 Aug. PMID 6812052, Free PMC Article
  5. Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. Villani G, et al. J Biol Chem, 1981 Aug 10. PMID 6790535

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication, synthesis of primer IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA replication, synthesis of primer IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of alpha DNA polymerase:primase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha DNA polymerase:primase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA primase subunit 2
Names
CG5553-PA
DNA polymerase alpha 58,000 beta subunit
DNA polymerase alpha 60,000 beta subunit
DNA polymerase alpha 60kD
DNA polymerase alpha 60kD subunit
DNA primase
DNA replication primer
DNApol-alpha60
DNAprim
Prim2-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    20359833..20361585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143744.4 → NP_652001.2  DNA primase subunit 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652001.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U9Q5, Q9VPH2
    UniProtKB/TrEMBL
    I1WYG8
    Related
    FBpp0077899
    Conserved Domains (1) summary
    cd07322
    Location:30 → 459
    PriL_PriS_Eukaryotic; Eukaryotic core primase: Large subunit, PriL
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VPH2.2 Q9VPH2

Gene LinkOut

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Chemical Information
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