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pnr - pannier

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and protein heterodimerization activity. Involved in several processes, including heart development; pericardial nephrocyte differentiation; and regulation of gene expression. Acts upstream of with a positive effect on imaginal disc fusion, thorax closure. Located in nucleus. Is expressed in several structures, including amnioserosa anlage; anterior-posterior subdivision of organism; cardiogenic mesoderm; epithelium; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including adenocarcinoma (multiple); artery disease (multiple); atrial fibrillation (multiple); congenital heart disease (multiple); and pancreatic hypoplasia-diabetes-congenital heart disease syndrome. Orthologous to several human genes including GATA5 (GATA binding protein 5). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to pnr

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Species Gene Architecture aa