g garnet [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: gprovided by FlyBase
Official Full Name: garnetprovided by FlyBase
Primary source: FLYBASE:FBgn0001087
Locus tag: Dmel_CG10986
See related: AllianceGenome:FB:FBgn0001087
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AP-3delta; AP3delta; apl5; CG10986; cg11197; CG11197; delta; Dmel\CG10986; l(1)Mc19
Summary: Predicted to enable cargo adaptor activity. Involved in several processes, including compound eye pigmentation; determination of adult lifespan; and eye pigment granule organization. Located in Golgi stack; endoplasmic reticulum; and late endosome. Is expressed in several structures, including adult head; embryonic/larval salivary gland; imaginal disc; and ovariole. Human ortholog(s) of this gene implicated in Hermansky-Pudlak syndrome. Orthologous to human AP3D1 (adaptor related protein complex 3 subunit delta 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 12B4-12B4; 1-45 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (13727204..13736278, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (13621237..13630311, complement)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Atg2 and ArfGAP1 may have roles in modifying the eye pigmentation phenotype of AP-3 mutants in Drosophila melanogaster
Title: Identification of Atg2 and ArfGAP1 as Candidate Genetic Modifiers of the Eye Pigmentation Phenotype of Adaptor Protein-3 (AP-3) Mutants in Drosophila melanogaster.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables cargo adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Golgi to endosome transport	NAS Non-traceable Author Statement more info	PubMed
involved_in Golgi to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch receptor processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in compound eye pigmentation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye pigment biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in eye pigment biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular transport	TAS Traceable Author Statement more info	PubMed
involved_in lysosomal transport	TAS Traceable Author Statement more info	PubMed
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in ommochrome biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein targeting to vacuole	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle budding from endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle membrane organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-3 adaptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of AP-3 adaptor complex	IEA Inferred from Electronic Annotation more info
part_of AP-3 adaptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in Golgi stack	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi-associated vesicle	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
part_of membrane coat	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic endosome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: garnet

Names: AP-3, delta subunit; CG10986-PB; CG10986-PD; CG10986-PF; adaptor protein complex 3, delta subunit; g-PB; g-PD; g-PF; lethal(1)Mc19; salmon

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

13727204..13736278 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001272599.1 → NP_001259528.1 garnet, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259528.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PHJ5, Q6NNU5

Conserved Domains (4) summary

pfam01602
Location:33 → 578

Adaptin_N; Adaptin N terminal region

pfam06375
Location:687 → 839

BLVR; Bovine leukaemia virus receptor (BLVR)

pfam12717
Location:193 → 249

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:152 → 173

HEAT; HEAT repeat [structural motif]
NM_001272600.1 → NP_001259529.1 garnet, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001259529.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PJM7, Q6NNU5

Conserved Domains (4) summary

pfam01602
Location:1 → 511

Adaptin_N; Adaptin N terminal region

pfam06375
Location:620 → 773

BLVR; Bovine leukaemia virus receptor (BLVR)

pfam12717
Location:126 → 199

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:85 → 106

HEAT; HEAT repeat [structural motif]
NM_080046.3 → NP_524785.2 garnet, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524785.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NNU5

Related

FBpp0073673

Conserved Domains (4) summary

pfam01602
Location:33 → 578

Adaptin_N; Adaptin N terminal region

pfam06375
Location:687 → 840

BLVR; Bovine leukaemia virus receptor (BLVR)

pfam12717
Location:193 → 266

Cnd1; non-SMC mitotic condensation complex subunit 1

sd00044
Location:152 → 173

HEAT; HEAT repeat [structural motif]