lin7c lin-7 homolog C (C. elegans) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lin7cprovided by ZNC
Official Full Name: lin-7 homolog C (C. elegans)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041011-2
See related: Ensembl:ENSDARG00000027322 AllianceGenome:ZFIN:ZDB-GENE-041011-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb75b09; wu:fb75b09; zgc:101881
Summary: Enables L27 domain binding activity. Acts upstream of or within maintenance of epithelial cell apical/basal polarity. Predicted to be located in bicellular tight junction and plasma membrane. Predicted to be part of MPP7-DLG1-LIN7 complex. Predicted to be active in basolateral plasma membrane; cell-cell junction; and synapse. Is expressed in several structures, including eye; neural rod; neural tube; neuroepithelial cell; and optic vesicle. Orthologous to human LIN7C (lin-7 homolog C, crumbs cell polarity complex component). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (31902333..31921642, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (31631183..31650441, complement)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb93a04.x1 (e-PCR)
- UniSTS:191778

fb75b09.x1 (e-PCR)
- UniSTS:187482

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L27 domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within exocytosis	IEA Inferred from Electronic Annotation more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within maintenance of epithelial cell apical/basal polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic assembly at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic vesicle transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MPP7-DLG1-LIN7 complex	IBA Inferred from Biological aspect of Ancestor more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein lin-7 homolog C

Names: neuroepithelial polarity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004672.2 → NP_001004672.1 protein lin-7 homolog C

See identical proteins and their annotated locations for NP_001004672.1

Status: PROVISIONAL

Source sequence(s)

AY584748

UniProtKB/TrEMBL

B2GTJ0, Q66IB0

Conserved Domains (2) summary

cd00992
Location:91 → 172

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:14 → 66

L27; L27 domain
NM_001362514.1 → NP_001349443.1 protein lin-7 homolog C

Status: VALIDATED

Source sequence(s)

AL935207

UniProtKB/TrEMBL

B2GTJ0, Q66IB0

Related

ENSDARP00000118823.1, ENSDART00000146720.3

Conserved Domains (2) summary

cd00992
Location:91 → 172

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

pfam02828
Location:14 → 66

L27; L27 domain