kif2a kinesin family member 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif2aprovided by ZNC
Official Full Name: kinesin family member 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-111
See related: Ensembl:ENSDARG00000043571 AllianceGenome:ZFIN:ZDB-GENE-040912-111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fj55b02; wu:fj55b02; zgc:103670
Summary: Predicted to enable ATP binding activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within several processes, including habituation; swimming behavior; and transmission of nerve impulse. Predicted to be located in cytoplasm and microtubule. Is expressed in head; hindbrain; and midbrain. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 3. Orthologous to human KIF2A (kinesin family member 2A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (12925378..12948931)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (12887661..12911226)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within habituation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swimming behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: kinesin-like protein KIF2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004664.3 → NP_001004664.3 kinesin-like protein KIF2A

Status: VALIDATED

Source sequence(s)

CT610644, CU463105, EB916181, EB924328

UniProtKB/TrEMBL

A0A8M1N222, A0A8M2BE76, F1RAK1

Related

ENSDARP00000079812.5, ENSDART00000085377.7

Conserved Domains (1) summary

cd01367
Location:236 → 564

KISc_KIF2_like; Kinesin motor domain, KIF2-like group

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007119.7 Reference GRCz11 Primary Assembly

Range

12925378..12948931

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005166830.5 → XP_005166887.1 kinesin-like protein KIF2A isoform X1

UniProtKB/TrEMBL

A0A8M1N222, A0A8M2BEB6

Conserved Domains (2) summary

smart00129
Location:236 → 572

KISc; Kinesin motor, catalytic domain. ATPase

cd01367
Location:236 → 564

KISc_KIF2_like; Kinesin motor domain, KIF2-like group