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Adk3 Adenosine kinase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44750, updated on 4-Jan-2025

Summary

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Official Symbol
Adk3provided by FlyBase
Official Full Name
Adenosine kinase 3provided by FlyBase
Primary source
FLYBASE:FBgn0026602
Locus tag
Dmel_CG1851
See related
AllianceGenome:FB:FBgn0026602
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Adk43A; Ady; ady43A; Ady43A; CG1851; DmAdk3; Dmel\CG1851
Summary
Predicted to enable adenosine kinase activity. Predicted to be involved in purine nucleobase metabolic process. Predicted to be active in cytosol and nucleus. Is expressed in mesoderm anlage and organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Adk3 in Genome Data Viewer
Location:
43A1-43A2; 2-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7243024..7245776, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3130529..3133281, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene prickle Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43a Neighboring gene long non-coding RNA:CR45280 Neighboring gene Growth arrest and DNA damage-inducible 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A regulatory code for neurogenic gene expression in the Drosophila embryo. Markstein M, et al. Development, 2004 May. PMID 15128669
  2. Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila. Patterson RA, et al. PLoS One, 2013. PMID 23637905, Free PMC Article
  3. The balance between isoforms of the prickle LIM domain protein is critical for planar polarity in Drosophila imaginal discs. Gubb D, et al. Genes Dev, 1999 Sep 1. PMID 10485852, Free PMC Article
  4. Inbreeding by environmental interactions affect gene expression in Drosophila melanogaster. Kristensen TN, et al. Genetics, 2006 Jul. PMID 16624914, Free PMC Article
  5. Differential response of Drosophila cell lines to extracellular adenosine. Fleischmannova J, et al. Insect Biochem Mol Biol, 2012 May. PMID 22266077

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables adenosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in purine nucleobase metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in purine ribonucleoside salvage IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adenosine kinase 3
Names
Adk3-PA
Ady43A
CG1851-PA
NP_651995.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7243024..7245776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143738.4 → NP_651995.1  adenosine kinase 3 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651995.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JWW6
    Related
    FBpp0088121
    Conserved Domains (2) summary
    cd01168
    Location:28 → 366
    adenosine_kinase; Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine ...
    PTZ00247
    Location:28 → 366
    PTZ00247; adenosine kinase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JWW6 Q7JWW6

Gene LinkOut

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