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Apc - APC-like

Enables beta-catenin binding activity. Involved in several processes, including nervous system development; oogenesis; and regionalization. Located in apical part of cell; axon; and cytosol. Part of beta-catenin destruction complex. Is expressed in several structures, including epidermis; motor neurons; neuron projection bundle of larval ventral nerve cord; presumptive embryonic/larval nervous system; and tendon cell. Used to study colorectal cancer and familial adenomatous polyposis 1. Human ortholog(s) of this gene implicated in several diseases, including Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; carcinoma (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human APC (APC regulator of WNT signaling pathway) and APC2 (APC regulator of WNT signaling pathway 2). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Apc

NCBI Orthologs

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Species Gene Architecture aa