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Cyp4e1 Cytochrome P450 4e1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44632, updated on 4-Jan-2025

Summary

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Official Symbol
Cyp4e1provided by FlyBase
Official Full Name
Cytochrome P450 4e1provided by FlyBase
Primary source
FLYBASE:FBgn0015034
Locus tag
Dmel_CG2062
See related
AllianceGenome:FB:FBgn0015034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
4e1; CG2062; CYP4e1; CYP4E1; Cyp4el; Dmel\CG2062; P-450; P450
Summary
Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in adult head; amnioserosa; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Cyp4e1 in Genome Data Viewer
Location:
44D1-44D1; 2-59 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8447451..8449745)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4334956..4337250)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4ad1 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop Neighboring gene Maltase A1 Neighboring gene Maltase A2 Neighboring gene Maltase A3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxins. Scott JG, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998 Nov. PMID 9972456
  2. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
  3. A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Terhzaz S, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26073628, Free PMC Article
  4. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Carareto CM, et al. Gene, 2014 Mar 1. PMID 24361809
  5. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4e1
Names
CG2062-PA
Cyp4e1-PA
cytochrome P450-4e1
NP_524771.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8447451..8449745
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080032.3 → NP_524771.1  cytochrome P450 4e1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V4T5
    Related
    FBpp0087825
    Conserved Domains (1) summary
    pfam00067
    Location:34 → 469
    p450; Cytochrome P450
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V4T5.1 Q9V4T5

Gene LinkOut

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