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ARHGEF35 Rho guanine nucleotide exchange factor 35 [ Homo sapiens (human) ]

Gene ID: 445328, updated on 27-Nov-2024

Summary

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Official Symbol
ARHGEF35provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 35provided by HGNC
Primary source
HGNC:HGNC:33846
See related
Ensembl:ENSG00000213214 AllianceGenome:HGNC:33846
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGEF5L
Expression
Broad expression in thyroid (RPKM 25.8), colon (RPKM 15.5) and 22 other tissues See more
Orthologs
all
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Genomic context

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See ARHGEF35 in Genome Data Viewer
Location:
7q35
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144186083..144195879, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145466560..145476351, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143883176..143892972, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AO member 1 pseudogene Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene CTAGE family member 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143901531-143902093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143902094-143902655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143904530-143905158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143905159-143905786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143906415-143907042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143935567-143936068 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:143947746-143948246 Neighboring gene olfactory receptor family 2 subfamily A member 20 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Transcriptional fates of human-specific segmental duplications in brain. Dougherty ML, et al. Genome Res, 2018 Oct. PMID 30228200, Free PMC Article
  2. Lineage-specific gene duplication and loss in human and great ape evolution. Fortna A, et al. PLoS Biol, 2004 Jul. PMID 15252450, Free PMC Article
  3. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Martin TD, et al. Cell Rep, 2017 Jul 11. PMID 28700943, Free PMC Article
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article
  5. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). Kennedy SA, et al. Nat Commun, 2020 Jan 24. PMID 31980649, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43692

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 35
Names
Rho guanine nucleotide exchange factor (GEF) 35
rho guanine nucleotide exchange factor 5-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003702.3 → NP_001003702.2  rho guanine nucleotide exchange factor 35

    See identical proteins and their annotated locations for NP_001003702.2

    Status: VALIDATED

    Source sequence(s)
    AC004889
    Consensus CDS
    CCDS34770.1
    UniProtKB/Swiss-Prot
    A5YM69, Q6ZUI2
    UniProtKB/TrEMBL
    A0A5F9ZGZ6
    Related
    ENSP00000367355.3, ENST00000378115.3
    Conserved Domains (1) summary
    pfam15441
    Location:1 → 478
    ARHGEF5_35; Rho guanine nucleotide exchange factor 5/35

  2. NM_001368318.1 → NP_001355247.1  rho guanine nucleotide exchange factor 35

    Status: VALIDATED

    Source sequence(s)
    MH721903
    Consensus CDS
    CCDS34770.1
    UniProtKB/Swiss-Prot
    A5YM69, Q6ZUI2
    UniProtKB/TrEMBL
    A0A5F9ZGZ6
    Related
    ENSP00000510684.1, ENST00000688754.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    144186083..144195879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654715.1 Reference GRCh38.p14 PATCHES

    Range
    140648..150440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332180.1 → XP_054188155.1  rho guanine nucleotide exchange factor 35 isoform X1

    UniProtKB/TrEMBL
    A0A5F9ZH52

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    145466560..145476351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358266.1 → XP_054214241.1  rho guanine nucleotide exchange factor 35 isoform X1

    UniProtKB/TrEMBL
    A0A5F9ZH52
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5YM69.1 GenPept UniProtKB/Swiss-Prot:A5YM69

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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