rg rugose [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: rgprovided by FlyBase
Official Full Name: rugoseprovided by FlyBase
Primary source: FLYBASE:FBgn0266098
Locus tag: Dmel_CG44835
See related: AllianceGenome:FB:FBgn0266098
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AKAP; Akap550; CG15464; CG15466; CG44835; CG6775; DAKAP550; Dmel\CG44835; fas; Rg
Old locus tag: Dmel_CG15464; Dmel_CG6775
Summary: Enables protein kinase A binding activity. Involved in several processes, including eye morphogenesis; learning or memory; and mushroom body development. Located in cytoplasm; membrane; and neuronal cell body. Is expressed in several structures, including CNS glial cell; adult brain cell body rind; adult head; brain; and gut section. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in common variable immunodeficiency 8. Orthologous to several human genes including LRBA (LPS responsive beige-like anchor protein). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 4E2-4F3; 1-11 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5085759..5254864)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (4979792..5148897)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

adult rg loss-of-function mutants exhibit defective social interactions, impaired habituation, aberrant locomotion, and hyperactivity.
Title: Drosophila mutants of the autism candidate gene neurobeachin (rugose) exhibit neuro-developmental disorders, aberrant synaptic properties, altered locomotion, and impaired adult social behavior and activity patterns.
This study demonistrated that functional homologies between Drosophila Rugose and mammalian NBEA that will help clarify the role of BEACH proteins in the development and function of the CNS in vivo.
Title: Drosophila rugose is a functional homolog of mammalian Neurobeachin and affects synaptic architecture, brain morphology, and associative learning.
Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis.
Title: Drosophila spoonbill encodes a dual-specificity A-kinase anchor protein essential for oogenesis.
results suggest that rugose gene encodes a secondary pigment cell specific function, and plays an essential role in determining the optic lobe's structure
Title: Mutation in rugose gene locus affects the pigment cell number and alters the optic lobe phenotype in the Drosophila visual system.
results suggest that rg is required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways
Title: rugose (rg), a Drosophila A kinase anchor protein, is required for retinal pattern formation and interacts genetically with multiple signaling pathways.
Rugose (rg) plays an important role in the integration of different signals required for the exact regulation of cone cell development and survival.
Title: Mutations in rugose promote cell type-specific apoptosis in the Drosophila eye.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein kinase A binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye photoreceptor cell development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mushroom body development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular junction development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in short-term memory	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rugose

Names: A kinase anchor protein 550; A-kinase anchoring protein; CG44835-PL; CG44835-PM; CG44835-PN; CG44835-PO; CG44835-PP; CG44835-PQ; CG44835-PR; drosophila A kinase anchor protein; facetious; pebbled; rg-PL; rg-PM; rg-PN; rg-PO; rg-PP; rg-PQ; rg-PR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.4 Reference assembly

Range

5085759..5254864

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297949.1 → NP_001284878.1 rugose, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284878.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JE60

Conserved Domains (9) summary

COG2319
Location:3191 → 3434

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1470 → 1787

MARCKS; MARCKS family

pfam02138
Location:2786 → 3062

Beach; Beige/BEACH domain

pfam06469
Location:2452 → 2633

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2657 → 2754

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:680 → 954

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:3185 → 3221

7WD40; WD40 repeat [structural motif]

cl02567
Location:3187 → 3431

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:256 → 404

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001297950.1 → NP_001284879.1 rugose, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001284879.1

Status: REVIEWED

UniProtKB/TrEMBL

X2JAH8

Conserved Domains (9) summary

COG2319
Location:3530 → 3773

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1434 → 1751

MARCKS; MARCKS family

pfam02138
Location:3125 → 3401

Beach; Beige/BEACH domain

pfam06469
Location:2791 → 2972

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2996 → 3093

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:634 → 918

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:3524 → 3560

7WD40; WD40 repeat [structural motif]

cl02567
Location:3526 → 3729

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:210 → 358

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001144686.2 → NP_001138158.2 rugose, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138158.2

Status: REVIEWED

UniProtKB/Swiss-Prot

O16024, Q8IRR9, Q961G8, Q9GP69, Q9GP70, Q9W4E2

Conserved Domains (9) summary

COG2319
Location:3211 → 3454

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1434 → 1751

MARCKS; MARCKS family

pfam02138
Location:2806 → 3082

Beach; Beige/BEACH domain

pfam06469
Location:2472 → 2653

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2677 → 2774

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:634 → 918

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:3205 → 3241

7WD40; WD40 repeat [structural motif]

cl02567
Location:3207 → 3451

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:210 → 358

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001144687.2 → NP_001138159.2 rugose, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138159.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0W8

Conserved Domains (9) summary

COG2319
Location:2948 → 3191

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1227 → 1544

MARCKS; MARCKS family

pfam02138
Location:2543 → 2819

Beach; Beige/BEACH domain

pfam06469
Location:2209 → 2390

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2414 → 2511

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:427 → 711

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2942 → 2978

7WD40; WD40 repeat [structural motif]

cl02567
Location:2944 → 3188

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:210 → 358

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001042796.3 → NP_001036261.3 rugose, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036261.3

Status: REVIEWED

UniProtKB/TrEMBL

Q0KHV9

Conserved Domains (9) summary

COG2319
Location:3464 → 3707

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1424 → 1741

MARCKS; MARCKS family

pfam02138
Location:3059 → 3335

Beach; Beige/BEACH domain

pfam06469
Location:2725 → 2906

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2930 → 3027

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:634 → 908

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:3458 → 3494

7WD40; WD40 repeat [structural motif]

cl02567
Location:3460 → 3663

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:210 → 358

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_001144685.2 → NP_001138157.2 rugose, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001138157.2

Status: REVIEWED

UniProtKB/TrEMBL

B7Z0X3

Conserved Domains (9) summary

COG2319
Location:3145 → 3388

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1424 → 1741

MARCKS; MARCKS family

pfam02138
Location:2740 → 3016

Beach; Beige/BEACH domain

pfam06469
Location:2406 → 2587

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2611 → 2708

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:634 → 908

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:3139 → 3175

7WD40; WD40 repeat [structural motif]

cl02567
Location:3141 → 3385

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:210 → 358

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
NM_167028.3 → NP_726978.2 rugose, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726978.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9W4E2

Conserved Domains (9) summary

COG2319
Location:2984 → 3227

WD40; WD40 repeat [General function prediction only]

pfam02063
Location:1263 → 1580

MARCKS; MARCKS family

pfam02138
Location:2579 → 2855

Beach; Beige/BEACH domain

pfam06469
Location:2245 → 2426

DUF1088; Domain of Unknown Function (DUF1088)

pfam14844
Location:2450 → 2547

PH_BEACH; PH domain associated with Beige/BEACH

pfam15787
Location:473 → 747

DUF4704; Domain of unknown function (DUF4704)

sd00039
Location:2978 → 3014

7WD40; WD40 repeat [structural motif]

cl02567
Location:2980 → 3224

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl22861
Location:256 → 404

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...