hnmt histamine N-methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: hnmtprovided by ZNC
Official Full Name: histamine N-methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-157
See related: Ensembl:ENSDARG00000012796 AllianceGenome:ZFIN:ZDB-GENE-040801-157
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: HMT; zgc:100917
Summary: Predicted to enable histamine N-methyltransferase activity. Predicted to be involved in histamine catabolic process and methylation. Predicted to be located in cytoplasm. Is expressed in adaxial cell; brain; and muscle pioneer. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive intellectual developmental disorder 51; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (10105852..10145795, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (10134479..10174422, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histamine N-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in histamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in methylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histamine N-methyltransferase

NP_001003636.1

EC 2.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003636.1 → NP_001003636.1 histamine N-methyltransferase

See identical proteins and their annotated locations for NP_001003636.1

Status: PROVISIONAL

Source sequence(s)

BC078250

UniProtKB/Swiss-Prot

Q6DC37

Related

ENSDARP00000004085.5, ENSDART00000004745.8

Conserved Domains (1) summary

cl17173
Location:132 → 187

AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...