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rab35b RAB35, member RAS oncogene family b [ Danio rerio (zebrafish) ]

Gene ID: 445154, updated on 9-Dec-2024

Summary

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Official Symbol
rab35bprovided by ZNC
Official Full Name
RAB35, member RAS oncogene family bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-62
See related
Ensembl:ENSDARG00000058425 AllianceGenome:ZFIN:ZDB-GENE-040801-62
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
rab35; sb:eu777; dZ146N9.2; zgc:100812; si:busm1-146n9.2
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within cilium assembly and determination of left/right symmetry. Predicted to be active in endosome membrane and plasma membrane. Is expressed in Kupffer's vesicle and testis. Orthologous to human RAB35 (RAB35, member RAS oncogene family). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See rab35b in Genome Data Viewer
Location:
chromosome: 8
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (3649070..3674506)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (3590321..3615757)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene paxillin b Neighboring gene GCN1 activator of EIF2AK4 Neighboring gene BICD family-like cargo adapter 1 Neighboring gene BICD family like cargo adaptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during zebrafish left-right organizer development. Aljiboury AA, et al. PLoS Genet, 2023 May. PMID 37186603, Free PMC Article
  2. Rab35 controls cilium length, function and membrane composition. Kuhns S, et al. EMBO Rep, 2019 Oct 4. PMID 31432619, Free PMC Article
  3. Proteomic analysis of three gonad types of swamp eel reveals genes differentially expressed during sex reversal. Sheng Y, et al. Sci Rep, 2015 May 18. PMID 25985063, Free PMC Article
  4. Evolution and Expression of Paxillin Genes in Teleost Fish. Jacob AE, et al. PLoS One, 2016. PMID 27806088, Free PMC Article
  5. A plasmid library of full-length zebrafish rab proteins for in vivo cell biology. Hall TE, et al. Cell Logist, 2017. PMID 28396820, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings demonstrate roles for Rab35 in regulating cilium length.
    Title: Rab35 controls cilium length, function and membrane composition.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ras-related protein Rab-35b
NP_001003548.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003548.2 → NP_001003548.1  ras-related protein Rab-35b

    See identical proteins and their annotated locations for NP_001003548.1

    Status: PROVISIONAL

    Source sequence(s)
    BC077124
    UniProtKB/TrEMBL
    Q6DEJ0
    Related
    ENSDARP00000039450.6, ENSDART00000033152.7
    Conserved Domains (2) summary
    smart00175
    Location:9 → 170
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:3 → 201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    3649070..3674506
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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