tipin timeless interacting protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tipinprovided by ZNC
Official Full Name: timeless interacting proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-189
See related: Ensembl:ENSDARG00000036136 AllianceGenome:ZFIN:ZDB-GENE-040801-189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91928
Summary: Predicted to enable DNA binding activity. Predicted to be involved in DNA integrity checkpoint signaling; positive regulation of cell population proliferation; and replication fork arrest. Predicted to act upstream of or within DNA damage response and cell division. Predicted to be located in chromatin and nucleus. Predicted to be part of replication fork protection complex. Is expressed in alar plate midbrain region; eye; immature eye; optic tectum; and pharyngeal arch 3-7 skeleton. Orthologous to human TIPIN (TIMELESS interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (34236269..34240903)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (33965104..33969753)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	IEA Inferred from Electronic Annotation more info
involved_in DNA replication checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic intra-S DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in replication fork arrest	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within replication fork processing	IEA Inferred from Electronic Annotation more info
involved_in replication fork processing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of replication fork protection complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: TIMELESS-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003452.2 → NP_001003452.2 TIMELESS-interacting protein

Status: VALIDATED

Source sequence(s)

BC078398, EH562814

UniProtKB/Swiss-Prot

Q6DBR4

UniProtKB/TrEMBL

G1K2L6

Related

ENSDARP00000052473.3, ENSDART00000052474.6

Conserved Domains (1) summary

pfam07962
Location:75 → 153

Swi3; Replication Fork Protection Component Swi3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

34236269..34240903

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005168874.5 → XP_005168931.1 TIMELESS-interacting protein isoform X1

UniProtKB/Swiss-Prot

Q6DBR4

UniProtKB/TrEMBL

A0A8M2BGP4

Conserved Domains (1) summary

pfam07962
Location:75 → 153

Swi3; Replication Fork Protection Component Swi3