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cpa2 carboxypeptidase A2 (pancreatic) [ Danio rerio (zebrafish) ]

Gene ID: 445052, updated on 9-Dec-2024

Summary

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Official Symbol
cpa2provided by ZNC
Official Full Name
carboxypeptidase A2 (pancreatic)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040801-182
See related
Ensembl:ENSDARG00000010146 AllianceGenome:ZFIN:ZDB-GENE-040801-182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92530
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in endocrine system and pancreas. Orthologous to human CPA2 (carboxypeptidase A2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See cpa2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (16590636..16600816, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (16494236..16504723, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene structural maintenance of chromosomes 1B Neighboring gene carboxypeptidase A4 Neighboring gene ATPase H+ transporting V1 subunit E1a Neighboring gene solute carrier family 25 member 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development. Tehrani Z, et al. Development, 2011 Feb. PMID 21228001, Free PMC Article
  2. Multidimensional chromatin profiling of zebrafish pancreas to uncover and investigate disease-relevant enhancers. Bordeira-Carriço R, et al. Nat Commun, 2022 Apr 11. PMID 35410466, Free PMC Article
  3. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases. Akula S, et al. Dev Comp Immunol, 2022 Feb. PMID 34619175
  4. Carboxypeptidase A6 in zebrafish development and implications for VIth cranial nerve pathfinding. Lyons PJ, et al. PLoS One, 2010 Sep 24. PMID 20885977, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
carboxypeptidase A2
NP_001003446.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003446.2 → NP_001003446.2  carboxypeptidase A2 precursor

    Status: VALIDATED

    Source sequence(s)
    AI496886, BC076057, CN322024, CR376785
    UniProtKB/TrEMBL
    A0A8M1N162, F1QVD7, Q6DHB8
    Related
    ENSDARP00000014821.6, ENSDART00000011397.7
    Conserved Domains (2) summary
    pfam02244
    Location:27 → 97
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:115 → 420
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    16590636..16600816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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