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Tollo tollo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44497, updated on 9-Dec-2024

Summary

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Official Symbol
Tolloprovided by FlyBase
Official Full Name
tolloprovided by FlyBase
Primary source
FLYBASE:FBgn0029114
Locus tag
Dmel_CG6890
See related
AllianceGenome:FB:FBgn0029114
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6890; CT21344; Dmel\CG6890; dTLR8; dToll8; Tl-8; toll; TOLL 8; Toll-8; Toll8; tollo; tollo/toll-8
Summary
Enables receptor ligand activity. Involved in several processes, including convergent extension; peripheral nervous system neuron development; and regulation of protein glycosylation. Is active in plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic head; gut section; imaginal disc; and neurogenic region. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Tollo in Genome Data Viewer
Location:
71C1-71C1; 3-43 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15235619..15242832)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15228719..15235932)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44562 Neighboring gene Peroxiredoxin 1 Neighboring gene Bestrophin 4 Neighboring gene Bestrophin 3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo. Aoki K, et al. J Biol Chem, 2007 Mar 23. PMID 17264077
  2. Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells. Seppo A, et al. Development, 2003 Apr. PMID 12588858
  3. SARM: From immune regulator to cell executioner. Carty M, et al. Biochem Pharmacol, 2019 Mar. PMID 30633870
  4. Computational identification and experimental characterization of preferred downstream positions in human core promoters. Dreos R, et al. PLoS Comput Biol, 2021 Aug. PMID 34383743, Free PMC Article
  5. Three key subregions contribute to the function of the downstream RNA polymerase II core promoter. Theisen JW, et al. Mol Cell Biol, 2010 Jul. PMID 20457814, Free PMC Article

See all (112) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
    Title: Formation of polarized contractile interfaces by self-organized Toll-8/Cirl GPCR asymmetry.
  2. Tollo expression in the motoneuron is both necessary and sufficient for regulating neuromuscular junction growth.
    Title: Retrograde neurotrophin signaling through Tollo regulates synaptic growth in Drosophila.
  3. findings show Toll-8 (Tollo) plays an important role in controlling the respiratory epithelium immune response; data indicate that, by antagonizing the IMD pathway, Tollo is preventing over-activation of the antibacterial response in the airway epithelium
    Title: Toll-8/Tollo negatively regulates antimicrobial response in the Drosophila respiratory epithelium.
  4. Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing.
    Title: Ectopic expression of Tollo/Toll-8 antagonizes Dpp signaling and induces cell sorting in the Drosophila wing.
  5. tollo/toll-8 signaling influences flux through several processing steps that affect the maturation of N-linked glycans
    Title: Dynamic developmental elaboration of N-linked glycan complexity in the Drosophila melanogaster embryo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables receptor ligand activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axis elongation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in convergent extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peripheral nervous system neuron development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tollo
Names
CG6890-PA
Toll-8
Tollo-PA
toll receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15235619..15242832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080018.2 → NP_524757.1  tollo [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524757.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2XXW0, Q9V477
    Related
    FBpp0075360
    Conserved Domains (5) summary
    smart00255
    Location:1076 → 1211
    TIR; Toll - interleukin 1 - resistance
    COG4886
    Location:210 → 656
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:276 → 558
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:260 → 283
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:815 → 875
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V477.1 Q9V477

Gene LinkOut

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