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CG46339 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44359, updated on 4-Jan-2025

Summary

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Official Symbol
CG46339provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0285963
Locus tag
Dmel_CG46339
See related
AllianceGenome:FB:FBgn0285963
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH07466; CG5518; Dmel\CG46339; sda; slamdance
Summary
Enables aminopeptidase activity. Involved in several processes, including cell dedifferentiation; germ-line stem-cell niche homeostasis; and male germ-line stem cell population maintenance. Predicted to be active in cytoplasm; extracellular space; and membrane. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG46339 in Genome Data Viewer
Location:
97D7-97D9; 3-92 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26915761..26945309)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22741483..22771031)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rough Neighboring gene Transcript 48 Neighboring gene Ets at 97D Neighboring gene transfer RNA:Glutamine-TTG 1-2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptome Profiling Following Neuronal and Glial Expression of ALS-Linked SOD1 in Drosophila. Kumimoto EL, et al. G3 (Bethesda), 2013 Apr 9. PMID 23550139, Free PMC Article
  2. An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation. Lim C, et al. Cell Rep, 2015 Oct 13. PMID 26440886, Free PMC Article
  3. Seizure-suppressor genes: can they help spearhead the discovery of novel therapeutic targets for epilepsy? Silva-Cardoso GK, et al. Expert Opin Ther Targets, 2023 Jul-Dec. PMID 37589085, Free PMC Article
  4. Cellular mechanisms underlying adult tissue plasticity in Drosophila. Nagai H, et al. Fly (Austin), 2022 Dec. PMID 35470772, Free PMC Article
  5. Genetic screen for genes involved in Chk2 signaling in Drosophila. Park SY, et al. Mol Cells, 2008 Oct 31. PMID 18612247

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Sda promotes spermatogonial dedifferentiation during aging and regeneration. Sda is required for accumulation of mature DE-cadherin.
    Title: An Aminopeptidase in the Drosophila Testicular Niche Acts in Germline Stem Cell Maintenance and Spermatogonial Dedifferentiation.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables aminopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell dedifferentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG46339-PA
CG46339-PB
CG46339-PC
CG46339-PD
CG46339-PE
CG46339-PF
slamdance
NP_001097939.1
NP_001247323.1
NP_001263001.1
NP_001350863.1
NP_001350864.1
NP_652744.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    26915761..26945309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276072.1 → NP_001263001.1  uncharacterized protein Dmel_CG46339, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263001.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH77
    Conserved Domains (3) summary
    cd09601
    Location:297 → 769
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:296 → 698
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:846 → 1138
    ERAP1_C; ERAP1-like C-terminal domain

  2. NM_001260394.2 → NP_001247323.1  uncharacterized protein Dmel_CG46339, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7L8
    Conserved Domains (3) summary
    cd09601
    Location:186 → 658
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:185 → 587
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:735 → 1027
    ERAP1_C; ERAP1-like C-terminal domain

  3. NM_001104469.3 → NP_001097939.1  uncharacterized protein Dmel_CG46339, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097939.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRD7
    Conserved Domains (2) summary
    cd09601
    Location:285 → 757
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:834 → 1114
    ERAP1_C; ERAP1-like C-terminal domain

  4. NM_144487.3 → NP_652744.2  uncharacterized protein Dmel_CG46339, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652744.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T6B0, Q9VBA3, Q9Y131
    Related
    FBpp0422658
    Conserved Domains (2) summary
    cd09601
    Location:174 → 646
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:723 → 1003
    ERAP1_C; ERAP1-like C-terminal domain

  5. NM_001363936.1 → NP_001350864.1  uncharacterized protein Dmel_CG46339, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JRD7
    Conserved Domains (2) summary
    cd09601
    Location:285 → 757
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:834 → 1114
    ERAP1_C; ERAP1-like C-terminal domain

  6. NM_001363935.1 → NP_001350863.1  uncharacterized protein Dmel_CG46339, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T6B0, Q9VBA3, Q9Y131
    Conserved Domains (2) summary
    cd09601
    Location:174 → 646
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam11838
    Location:723 → 1003
    ERAP1_C; ERAP1-like C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7L8 A0A0B4K7L8
A0A0B4KH77 A0A0B4KH77
A8JRD7 A8JRD7
Q9VBA3 Q9VBA3

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