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Shark - SH2 ankyrin repeat kinase

Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in several processes, including dorsal appendage formation; dorsal closure, elongation of leading edge cells; and maintenance of epithelial cell apical/basal polarity. Located in cell cortex. Is expressed in several structures, including ectoderm; embryonic/larval salivary gland; epithelium; germline cell; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa