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Shark SH2 ankyrin repeat kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44353, updated on 9-Dec-2024

Summary

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Official Symbol
Sharkprovided by FlyBase
Official Full Name
SH2 ankyrin repeat kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0015295
Locus tag
Dmel_CG18247
See related
AllianceGenome:FB:FBgn0015295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18247; Dmel\CG18247; dShark; dtk7; Dtk7; l(2)W4; l(2R)W4; shark; SHARK; Syk; SYK/SHARK; Tk7
Summary
Predicted to enable non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in several processes, including dorsal appendage formation; dorsal closure, elongation of leading edge cells; and maintenance of epithelial cell apical/basal polarity. Located in cell cortex. Is expressed in several structures, including ectoderm; embryonic/larval salivary gland; epithelium; germline cell; and gut section. Human ortholog(s) of this gene implicated in immunodeficiency 48 and severe combined immunodeficiency. Orthologous to human ZAP70 (zeta chain of T cell receptor associated protein kinase 70). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Shark in Genome Data Viewer
Location:
52F8-52F8; 2-78 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16199426..16202884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12086931..12090389, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Lipoyltransferase 1 Neighboring gene transfer RNA:Glutamine-CTG 1-1 Neighboring gene mrj Neighboring gene transfer RNA:Glutamic acid-TTC 1-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Shark, a Src homology 2, ankyrin repeat, tyrosine kinase, is expressed on the apical surfaces of ectodermal epithelia. Ferrante AW Jr, et al. Proc Natl Acad Sci U S A, 1995 Mar 14. PMID 7892198, Free PMC Article
  2. Draper/CED-1 mediates an ancient damage response to control inflammatory blood cell migration in vivo. Evans IR, et al. Curr Biol, 2015 Jun 15. PMID 26028435, Free PMC Article
  3. Cytoskeletal Exposure in the Regulation of Immunity and Initiation of Tissue Repair. Gordon O, et al. Bioessays, 2019 Jul. PMID 31157930
  4. α-actinin accounts for the bioactivity of actin preparations in inducing STAT target genes in Drosophila melanogaster. Gordon O, et al. Elife, 2018 Sep 27. PMID 30260317, Free PMC Article
  5. Natural history and functional divergence of protein tyrosine kinases. Gu J, et al. Gene, 2003 Oct 23. PMID 14604791

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Draper-Src42A-Shark interactions are strikingly similar to mammalian immunoreceptor-SFK-Syk signalling events in mammalian myeloid and lymphoid cells.
    Title: Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling.
  2. Required in follicle cells for cell migration and chorion deposition.
    Title: bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure TAS
Traceable Author Statement
more info
 PubMed 
involved_in dorsal closure, elongation of leading edge cells IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg chorion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of epithelial cell apical/basal polarity IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SH2 ankyrin repeat kinase
Names
CG18247-PA
Shark-PA
Src homology 2 ankyrin repeat tyrosine kinase
Src homology 2, ankyrin repeat, tyrosine kinase
Src homology2, ankyrin repeat, tyrosine kinase
tyrosine kinase 7
NP_524743.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16199426..16202884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080004.4 → NP_524743.2  SH2 ankyrin repeat kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524743.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24145, Q26299, Q9V7K5
    Related
    FBpp0086382
    Conserved Domains (8) summary
    smart00219
    Location:662 → 921
    TyrKc; Tyrosine kinase, catalytic domain
    cd10347
    Location:8 → 91
    SH2_Nterm_shark_like; N-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins
    cd10348
    Location:287 → 395
    SH2_Cterm_shark_like; C-terminal Src homology 2 (SH2) domain found in SH2 domains, ANK, and kinase domain (shark) proteins
    cd00204
    Location:117 → 241
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd05060
    Location:666 → 926
    PTKc_Syk_like; Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases
    pfam12796
    Location:158 → 247
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:224 → 274
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:153 → 184
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24145.2 Q24145

Gene LinkOut

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