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Ms Myosuppressin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44324, updated on 9-Dec-2024

Summary

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Official Symbol
Msprovided by FlyBase
Official Full Name
Myosuppressinprovided by FlyBase
Primary source
FLYBASE:FBgn0011581
Locus tag
Dmel_CG6440
See related
AllianceGenome:FB:FBgn0011581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg6440; CG6440; Dm-MS; Dmel\CG6440; dms; Dms; DMS; Drm-MS; Drome-MS; FLRFa; MEMS; MS; Nems
Summary
Enables neuropeptide receptor binding activity. Involved in several processes, including adult locomotory behavior; negative regulation of heart rate; and neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including DMS neuron; adult brain; central nervous system; crop; and embryonic central brain neurons. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
95F14-95F14; 3-84 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24341551..24343825)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20167273..20169547)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Dis3 Neighboring gene uncharacterized protein Neighboring gene mir-1015 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Golgin-84

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial and temporal expression identify dromyosuppressin as a brain-gut peptide in Drosophila melanogaster. McCormick J, et al. J Comp Neurol, 1993 Dec 8. PMID 8308172
  2. Mating regulates neuromodulator ensembles at nerve termini innervating the Drosophila reproductive tract. Heifetz Y, et al. Curr Biol, 2014 Mar 31. PMID 24631240, Free PMC Article
  3. Structure-activity and immunochemical data provide evidence of developmental- and tissue-specific myosuppressin signaling. Dickerson M, et al. Peptides, 2012 Aug. PMID 22613084, Free PMC Article
  4. A nonpeptide provides insight into mechanisms that regulate Drosophila melanogaster heart contractions. Mispelon M, et al. Peptides, 2003 Oct. PMID 14706539
  5. Functional redundancy of FMRFamide-related peptides at the Drosophila larval neuromuscular junction. Hewes RS, et al. J Neurosci, 1998 Sep 15. PMID 9736637, Free PMC Article

See all (106) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables neuropeptide hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
 PubMed 
enables neuropeptide receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of digestive system process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of heart contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of heart rate IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of smooth muscle contraction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuropeptide signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neuropeptide signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
myosuppressin
Names
CG6440-PA
CG6440-PB
CG6440-PC
Drm-myosuppressin
Ms-PA
Ms-PB
Ms-PC
TDVDHVFLRFamide
dromyosuppressin
neomyosuppressin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24341551..24343825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300574.1 → NP_001287503.1  myosuppressin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287503.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41494, P61849, Q9VC91
    UniProtKB/TrEMBL
    A0A0B4KGT7

  2. NM_080511.3 → NP_536772.1  myosuppressin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536772.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41494, P61849, Q9VC91
    UniProtKB/TrEMBL
    A0A0B4KGT7
    Related
    FBpp0083991

  3. NM_001275982.1 → NP_001262911.1  myosuppressin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262911.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P41494, P61849, Q9VC91
    UniProtKB/TrEMBL
    A0A0B4KGT7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGT7 A0A0B4KGT7
P61849.1 P61849

Gene LinkOut

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