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Vha16-1 Vacuolar H[+] ATPase 16kD subunit 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44307, updated on 9-Dec-2024

Summary

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Official Symbol
Vha16-1provided by FlyBase
Official Full Name
Vacuolar H[+] ATPase 16kD subunit 1provided by FlyBase
Primary source
FLYBASE:FBgn0262736
Locus tag
Dmel_CG3161
See related
AllianceGenome:FB:FBgn0262736
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
ATP6V0C; BcDNA:SD02875; CG3161; Dmel\CG3161; DucC; EP2372; MRE15; v-ATPase; V-ATPase; Vha1; vha16; Vha16; vha16-1; Vhac
Summary
Predicted to contribute to proton-transporting ATPase activity, rotational mechanism. Involved in dsRNA transport and vacuolar acidification. Located in fusome. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including anterior-posterior subdivision of organism; female germline cell; follicle cell; ganglia; and somatic muscle cell. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Vha16-1 in Genome Data Viewer
Location:
42B2-42B2; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6625242..6633090, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2512747..2520595, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene jing Neighboring gene stable intronic sequence RNA CR46361 Neighboring gene uncharacterized protein Neighboring gene Trap1 Neighboring gene Brahma associated protein 170kD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequence of a cDNA from Drosophila coding for the 16 kD proteolipid component of the vacuolar H(+)-ATPase. Meagher L, et al. Nucleic Acids Res, 1990 Nov 25. PMID 2147478, Free PMC Article
  2. Reduced Gut Acidity Induces an Obese-Like Phenotype in Drosophila melanogaster and in Mice. Lin WS, et al. PLoS One, 2015. PMID 26436771, Free PMC Article
  3. Tissue-specific distribution and variation of the channel-forming protein ductin during development of Drosophila melanogaster. Bohrmann J, et al. Int J Dev Biol, 2000 Dec. PMID 11206329
  4. Microinjected antisera against ductin affect gastrulation in Drosophila melanogaster. Bohrmann J, et al. Int J Dev Biol, 1998 Jul. PMID 9712526
  5. Evidence that the 16 kDa proteolipid (subunit c) of the vacuolar H(+)-ATPase and ductin from gap junctions are the same polypeptide in Drosophila and Manduca: molecular cloning of the Vha16k gene from Drosophila. Finbow ME, et al. J Cell Sci, 1994 Jul. PMID 7983150

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. lysosomal-associated functions regulated by the TFEB-V-ATPase axis might play a conserved role in shaping cell fate.
    Title: Control of lysosomal biogenesis and Notch-dependent tissue patterning by components of the TFEB-V-ATPase axis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
contributes_to proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proton transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vacuolar acidification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in fusome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of plasma membrane proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of proton-transporting V-type ATPase, V0 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V0 domain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
vacuolar H[+] ATPase 16kD subunit 1
Names
CG3161-PA
CG3161-PB
CG3161-PC
CG3161-PD
Vha16-1-PA
Vha16-1-PB
Vha16-1-PC
Vha16-1-PD
c subunit
ductin
ductin subunit C
ductin, vacuolar H(+)-ATPase subunit C proteolipid
mRNA-like ncRNA in embryogenesis 15
vacuolar H[+] ATPase 16kD subunit
vacuolar H[+] ATPase subunit 16-1
vacuolar H[+]-ATPase c subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    6625242..6633090 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057453.5 → NP_476801.1  vacuolar H[+] ATPase 16kD subunit 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476801.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
    Related
    FBpp0085483
    Conserved Domains (2) summary
    TIGR01100
    Location:15 → 122
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:90 → 157
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

  2. NM_165474.3 → NP_724474.1  vacuolar H[+] ATPase 16kD subunit 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724474.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
    Related
    FBpp0085484
    Conserved Domains (2) summary
    TIGR01100
    Location:15 → 122
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:90 → 157
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

  3. NM_165476.3 → NP_724476.1  vacuolar H[+] ATPase 16kD subunit 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724476.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
    Related
    FBpp0085486
    Conserved Domains (2) summary
    TIGR01100
    Location:15 → 122
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:90 → 157
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins

  4. NM_165475.3 → NP_724475.1  vacuolar H[+] ATPase 16kD subunit 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4UZ55, P23380, Q0E9N6, Q53XD4, Q9V9D2
    Related
    FBpp0085485
    Conserved Domains (2) summary
    TIGR01100
    Location:15 → 122
    V_ATP_synt_C; vacuolar ATP synthase 16 kDa proteolipid subunit
    cd18176
    Location:90 → 157
    ATP-synt_Vo_c_ATP6C_rpt2; V-type proton ATPase 16 kDa proteolipid subunit (ATP6C/ATP6V0C/ATP6L/ATPL) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23380.1 P23380

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