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ome omega [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44297, updated on 4-Jan-2025

Summary

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Official Symbol
omeprovided by FlyBase
Official Full Name
omegaprovided by FlyBase
Primary source
FLYBASE:FBgn0259175
Locus tag
Dmel_CG42280
See related
AllianceGenome:FB:FBgn0259175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BEST:LD21715; CG17705; CG32143; CG32145; CG42280; CG9370; Dmel\CG42280; LD21715; Ome; OMe
Old locus tag
Dmel_CG32143; Dmel_CG32145
Summary
Enables dipeptidyl-peptidase activity. Involved in proteolysis. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic foregut sensory structure; gland; and gut section. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; amyotrophic lateral sclerosis; autosomal dominant intellectual developmental disorder 33; spinal muscular atrophy; and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4); DPP6 (dipeptidyl peptidase like 6); and FAP (fibroblast activation protein alpha). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See ome in Genome Data Viewer
Location:
70E7-70F4; 3-42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (14672839..14747868)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (14665939..14740968)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene dally-like Neighboring gene long non-coding RNA:CR45888 Neighboring gene transfer RNA:initiator Methionine-CAT 1-4 Neighboring gene transfer RNA:initiator Methionine-CAT 1-5 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Dynein axonemal assembly factor 6 Neighboring gene goddard Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Trithorax-like Neighboring gene tRNA splicing endonuclease subunit 34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The cuticle proteins of Drosophila melanogaster: genetic localization of a second cluster of third-instar genes. Chihara CJ, et al. Genetics, 1986 Oct. PMID 3095183, Free PMC Article
  2. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara CJ, et al. J Insect Sci, 2005 Nov 2. PMID 17119608, Free PMC Article
  3. Global analysis of trans-splicing in Drosophila. McManus CJ, et al. Proc Natl Acad Sci U S A, 2010 Jul 20. PMID 20615941, Free PMC Article
  4. Computational identification of developmental enhancers: conservation and function of transcription factor binding-site clusters in Drosophila melanogaster and Drosophila pseudoobscura. Berman BP, et al. Genome Biol, 2004. PMID 15345045, Free PMC Article
  5. An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases. Huang X, et al. Transl Neurodegener, 2021 Mar 8. PMID 33685517, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromosome mapping and expression studies of ome are reported.
    Title: Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

mobile_element

  • Loc: 14721232-14723021 mobile_element_type = transposon:Rt1b{}999
  • Loc: 14725654-14728582 mobile_element_type = transposon:Doc{}1000

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dipeptidyl-peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
omega
Names
CG42280-PE
CG42280-PF
CG42280-PG
CG42280-PH
ome-PE
ome-PF
ome-PG
ome-PH
NP_001097606.1
NP_001137955.1
NP_001261844.1
NP_524739.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    14672839..14747868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001144483.2 → NP_001137955.1  omega, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137955.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R16
    Conserved Domains (4) summary
    COG1506
    Location:644 → 915
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:711 → 916
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:250 → 622
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
    pfam10500
    Location:18 → 150
    SR-25; Nuclear RNA-splicing-associated protein

  2. NM_001104136.2 → NP_001097606.1  omega, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A2RVG6
    Conserved Domains (3) summary
    COG1073
    Location:882 → 1028
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
    pfam00326
    Location:828 → 1033
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:367 → 739
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  3. NM_080000.4 → NP_524739.1  omega, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VUH1
    Related
    FBpp0288925
    Conserved Domains (3) summary
    COG1506
    Location:523 → 794
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:590 → 795
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:129 → 501
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  4. NM_001274915.1 → NP_001261844.1  omega, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCH6
    Conserved Domains (3) summary
    COG1506
    Location:505 → 776
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:572 → 777
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:111 → 483
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RVG6 A2RVG6
M9PCH6 M9PCH6
Q29R16 Q29R16
Q9VUH1 Q9VUH1

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