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Sara Smad anchor for receptor activation [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44263, updated on 9-Dec-2024

Summary

Official Symbol
Saraprovided by FlyBase
Official Full Name
Smad anchor for receptor activationprovided by FlyBase
Primary source
FLYBASE:FBgn0026369
Locus tag
Dmel_CG15667
See related
AllianceGenome:FB:FBgn0026369
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG15667; Dmel\CG15667; dSARA; sara; SARA
Summary
Enables protein phosphatase 1 binding activity. Involved in asymmetric stem cell division; intestinal stem cell homeostasis; and stem cell fate determination. Located in early endosome. Orthologous to human ZFYVE16 (zinc finger FYVE-type containing 16) and ZFYVE9 (zinc finger FYVE-type containing 9). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Sara in Genome Data Viewer
Location:
57E6-57E6; 2-95 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21481927..21487107)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (17369432..17374612)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A oxidase at 57D proximal Neighboring gene acyl-Coenzyme A oxidase at 57D distal Neighboring gene Syndecan Neighboring gene FK506-binding protein 14 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein phosphatase 1 binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in asymmetric stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
smad anchor for receptor activation
Names
CG15667-PA
Sara-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    21481927..21487107
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079990.3NP_524729.2  smad anchor for receptor activation [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524729.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K9H6, Q960V6
    Related
    FBpp0071564
    Conserved Domains (3) summary
    cd15729
    Location:522589
    FYVE_endofin; FYVE domain found in endofin and similar proteins
    pfam11409
    Location:614650
    SARA; Smad anchor for receptor activation (SARA)
    pfam11979
    Location:9591321
    DUF3480; Domain of unknown function (DUF3480)