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nbs nbs [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44259, updated on 4-Jan-2025

Summary

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Official Symbol
nbsprovided by FlyBase
Official Full Name
nbsprovided by FlyBase
Primary source
FLYBASE:FBgn0261530
Locus tag
Dmel_CG6754
See related
AllianceGenome:FB:FBgn0261530
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
6754; CG6754; Dmel\CG6754; dNbs1; Dnbs1; l(3)67BDp; l(3)67BDr; l(3)e77A1; Nbs; NBS; nbs1; Nbs1; NBS1
Summary
Predicted to enable damaged DNA binding activity. Involved in DNA metabolic process and intracellular signal transduction. Part of Mre11 complex. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; acute lymphoblastic leukemia; aplastic anemia; rectum cancer; and reproductive organ cancer (multiple). Orthologous to human NBN (nibrin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nbs in Genome Data Viewer
Location:
67C5-67C5; 3-31 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9720414..9723194, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9713514..9716294, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene visgun Neighboring gene small non-coding RNA 838 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene deflated Neighboring gene N(alpha)-acetyltransferase 60

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA damage responses in Drosophila nbs mutants with reduced or altered NBS function. Mukherjee S, et al. DNA Repair (Amst), 2009 Jul 4. PMID 19395318, Free PMC Article
  2. A powerful method combining homologous recombination and site-specific recombination for targeted mutagenesis in Drosophila. Gao G, et al. Proc Natl Acad Sci U S A, 2008 Sep 16. PMID 18772376, Free PMC Article
  3. Attenuating the DNA damage response to double-strand breaks restores function in models of CNS neurodegeneration. Tuxworth RI, et al. Brain Commun, 2019. PMID 32954257, Free PMC Article
  4. Phenotypic analysis of deflated/Ints7 function in Drosophila development. Rutkowski RJ, et al. Dev Dyn, 2009 May. PMID 19326441
  5. Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis. Gao G, et al. Proc Natl Acad Sci U S A, 2009 Jun 30. PMID 19520832, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila telomere capping protein HOAP interacts with DSB sensor proteins Mre11 and Nbs.
    Title: Drosophila telomere capping protein HOAP interacts with DSB sensor proteins Mre11 and Nbs.
  2. Study identified a stringent requirement for Mre11-Rad50-Nbs (MRN) function in telomere protection during early embryonic development.
    Title: Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.
  3. This suggests that Nbs and the Mre11/Rad50 complex play partially independent roles in telomere protection and that Nbs functions in both ATR- and ATM-controlled telomere protection pathways.
    Title: The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables damaged DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA duplex unwinding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via synthesis-dependent strand annealing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction in response to DNA damage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
  
involved_in telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Mre11 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Mre11 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Mre11 complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nbs
Names
CG6754-PD
CG6754-PE
lethal (3) 67BDp
lethal (3) 67BDr
nbs-PD
nbs-PE
nijmegen breakage syndrome
NP_001246702.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9720414..9723194 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259773.2 → NP_001246702.1  nbs, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246702.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NF67
    Conserved Domains (4) summary
    COG1716
    Location:8 → 99
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00027
    Location:115 → 171
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00060
    Location:3 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam16508
    Location:207 → 309
    NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein

  2. NM_143716.5 → NP_651973.4  nbs, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651973.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT40
    Conserved Domains (4) summary
    COG1716
    Location:8 → 99
    FHA; Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms]
    cd00027
    Location:115 → 171
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    cd00060
    Location:3 → 98
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    pfam16508
    Location:207 → 311
    NIBRIN_BRCT_II; Second BRCT domain on Nijmegen syndrome breakage protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NF67 M9NF67
Q95RC6 Q95RC6
Q9VT40 Q9VT40

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