ps pasilla [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: psprovided by FlyBase
Official Full Name: pasillaprovided by FlyBase
Primary source: FLYBASE:FBgn0261552
Locus tag: Dmel_CG42670
See related: AllianceGenome:FB:FBgn0261552
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE47781; CG16765; CG16776; CG16777; CG18509; CG42670; cg8144; CG8144; Dmel\CG42670; EP(3)3406; l(3)10615; NOVA1; Pasilla; PS
Old locus tag: Dmel_CG16765; Dmel_CG16777
Summary: Enables pre-mRNA intronic binding activity. Involved in positive regulation of RNA splicing and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Is expressed in several structures, including Malpighian tubule primordium; embryonic/larval midgut primordium; epithelium; gut section; and somatic trunk mesoderm derivative. Orthologous to human NOVA1 (NOVA alternative splicing regulator 1) and NOVA2 (NOVA alternative splicing regulator 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 85D16-85D17; 3-48 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (9417940..9455500)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (5243662..5281222)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Authors posit that pasilla-mediated processing of unspliced Orb2A mRNA integrates experience and internal state to control Orb2A protein abundance and long-term memory formation.
Title: Regulated Intron Removal Integrates Motivational State and Experience.
Splice sites are overrepresented in Pasilla binding motif clusters in D. melanogaster genes
Title: [Splice sites are overrepresented in Pasilla binding motif clusters in D. melanogaster genes].

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables pre-mRNA intronic binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: pasilla

Names: CG42670-PB; CG42670-PC; CG42670-PD; CG42670-PF; CG42670-PG; CG42670-PH; CG42670-PI; CG42670-PJ; CG42670-PK; CG42670-PL; CG42670-PM; CG42670-PN; CG42670-PO; CG42670-PP; CG42670-PQ; CG42670-PR; CG42670-PS; CG42670-PT; lethal (3) 10615; ps-PB; ps-PC; ps-PD; ps-PF; ps-PG; ps-PH; ps-PI; ps-PJ; ps-PK; ps-PL; ps-PM; ps-PN; ps-PO; ps-PP; ps-PQ; ps-PR; ps-PS; ps-PT

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

9417940..9455500

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001202270.2 → NP_001189199.1 pasilla, isoform N [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189199.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:488 → 551

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:67 → 132

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001043227.2 → NP_001036692.1 pasilla, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036692.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:488 → 551

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:67 → 132

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001202272.2 → NP_001189201.1 pasilla, isoform P [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189201.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:466 → 529

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:45 → 110

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001202274.2 → NP_001189203.1 pasilla, isoform O [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189203.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:488 → 551

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:67 → 132

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_169280.4 → NP_731351.3 pasilla, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731351.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:488 → 551

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:67 → 132

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001043230.3 → NP_001036695.1 pasilla, isoform K [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036695.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:466 → 529

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:45 → 110

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001202273.2 → NP_001189202.1 pasilla, isoform M [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189202.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:466 → 529

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:45 → 110

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_169281.4 → NP_731352.3 pasilla, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731352.3

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:488 → 551

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:67 → 132

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001275486.1 → NP_001262415.1 pasilla, isoform R [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262415.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A0A0B4JCX5, A0A0B4KFY5, A0A0B4KGY6, A0A0B4LGY5, A0A0B4LI06, Q0KI94, Q0KI96, Q8INP0, Q8T4D1, Q9GNC8, Q9GQN3, Q9GQN4, Q9VHD4, Q9VHD6

Conserved Domains (3) summary

cd09031
Location:694 → 762

KH-I_NOVA_rpt3; third type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22435
Location:274 → 345

KH-I_NOVA_rpt1; first type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)

cd22436
Location:367 → 436

KH-I_NOVA_rpt2; second type I K homology (KH) RNA-binding domain found in the family of neuro-oncological ventral antigen (Nova)
NM_001300324.1 → NP_001287253.1 pasilla, isoform T [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287253.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:532 → 595

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:111 → 176

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_169283.2 → NP_731354.1 pasilla, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731354.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWM9

Related

FBpp0081515

Conserved Domains (1) summary

cd02396
Location:34 → 99

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001043232.1 → NP_001036697.1 pasilla, isoform J [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036697.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:455 → 518

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:34 → 99

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001275485.1 → NP_001262414.1 pasilla, isoform Q [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262414.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:433 → 496

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:12 → 77

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001300323.1 → NP_001287252.1 pasilla, isoform S [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287252.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A023UKB8

Conserved Domains (2) summary

cd00105
Location:510 → 573

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:89 → 154

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001043226.1 → NP_001036691.1 pasilla, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036691.1

Status: REVIEWED

UniProtKB/TrEMBL

Q6AWM9

Conserved Domains (1) summary

cd02396
Location:78 → 143

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_001202271.2 → NP_001189200.1 pasilla, isoform L [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189200.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JCX5

Conserved Domains (2) summary

cd00105
Location:674 → 737

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:253 → 318

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_169284.2 → NP_731355.1 pasilla, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731355.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGS7

Related

FBpp0081516

Conserved Domains (2) summary

cd00105
Location:499 → 562

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:78 → 143

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
NM_169285.3 → NP_731356.1 pasilla, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731356.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8IGS7

Related

FBpp0081517

Conserved Domains (2) summary

cd00105
Location:477 → 540

KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...

cd02396
Location:56 → 121

PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...