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spen - split ends

Predicted to enable mRNA binding activity. Involved in several processes, including establishment of thoracic bristle planar orientation; nervous system development; and wing disc development. Located in nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; gland; imaginal disc; and larval central nervous system. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma. Orthologous to human SPEN (spen family transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]

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Species Gene Architecture aa