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slmo slowmo [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44132, updated on 9-Dec-2024

Summary

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Official Symbol
slmoprovided by FlyBase
Official Full Name
slowmoprovided by FlyBase
Primary source
FLYBASE:FBgn0029161
Locus tag
Dmel_CG9131
See related
AllianceGenome:FB:FBgn0029161
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9131; CT26166; Dmel\CG9131; kisir
Summary
Predicted to enable phosphatidic acid transfer activity. Involved in several processes, including germarium-derived oocyte differentiation; larval locomotory behavior; and peristalsis. Located in mitochondrion. Is expressed in several structures, including adult optic lobe; brain; embryonic/larval midgut primordium; gut section; and mesoderm. Orthologous to several human genes including PRELID3B (PRELI domain containing 3B). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See slmo in Genome Data Viewer
Location:
26B3-26B3; 2-18 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6046516..6048706, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6046516..6048706, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Phosphoribosylformylglycinamidine synthase Neighboring gene mir-966 stem loop Neighboring gene uncharacterized protein Neighboring gene Inositol phosphatase interacting protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slowmo is required for Drosophila germline proliferation. Reeve S, et al. Genesis, 2007 Feb. PMID 17245774
  2. Transcription defines the embryonic domains of cis-regulatory activity at the Drosophila bithorax complex. Drewell RA, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477928, Free PMC Article
  3. A novel family of mitochondrial proteins is represented by the Drosophila genes slmo, preli-like and real-time. Dee CT, et al. Dev Genes Evol, 2005 May. PMID 15700158
  4. Mutation in slowmo causes defects in Drosophila larval locomotor behaviour. Carhan A, et al. Invert Neurosci, 2004 Oct. PMID 14673704
  5. Overexpression screen in Drosophila identifies neuronal roles of GSK-3 beta/shaggy as a regulator of AP-1-dependent developmental plasticity. Franciscovich AL, et al. Genetics, 2008 Dec. PMID 18832361, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Not required in germline cells directly, but is required in somatic cyst cells responsible for maintaining germline survival in both sexes.
    Title: Slowmo is required for Drosophila germline proliferation.
  2. Here we provide evidence that, like Slmo, both the Prel and Retm proteins are localised to the mitochondria, indicating that the function of the PRELI/MSF1p' domain is specific to this organelle.
    Title: A novel family of mitochondrial proteins is represented by the Drosophila genes slmo, preli-like and real-time.
  3. We have identified a mutant slowmotion phenotype in first instar larval peristaltic behaviour of Drosophila that is associated with mitochondria and inhibition of neurotransmitter release.
    Title: Mutation in slowmo causes defects in Drosophila larval locomotor behaviour.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatidic acid transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in germarium-derived oocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peristalsis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
slowmo
Names
CG9131-PA
CG9131-PB
CG9131-PC
CG9131-PD
CG9131-PE
kisir
slmo-PA
slmo-PB
slmo-PC
slmo-PD
slmo-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6046516..6048706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298724.1 → NP_001285653.1  slowmo, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285653.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058T1, Q9V3U9
    UniProtKB/TrEMBL
    A4V0A1
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 168
    PRELI; PRELI-like family

  2. NM_001103624.2 → NP_001097094.1  slowmo, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097094.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058T1, Q9V3U9
    UniProtKB/TrEMBL
    A4V0A1
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 168
    PRELI; PRELI-like family

  3. NM_001144321.2 → NP_001137793.1  slowmo, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137793.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058T1, Q9V3U9
    UniProtKB/TrEMBL
    A4V0A1
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 168
    PRELI; PRELI-like family

  4. NM_079966.3 → NP_524705.1  slowmo, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524705.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058T1, Q9V3U9
    UniProtKB/TrEMBL
    A4V0A1
    Related
    FBpp0078849
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 168
    PRELI; PRELI-like family

  5. NM_164677.2 → NP_723148.1  slowmo, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723148.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q058T1, Q9V3U9
    UniProtKB/TrEMBL
    A4V0A1
    Related
    FBpp0078848
    Conserved Domains (1) summary
    pfam04707
    Location:15 → 168
    PRELI; PRELI-like family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V0A1 A4V0A1
Q9V3U9.1 Q9V3U9

Gene LinkOut

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