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TotA Turandot A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44121, updated on 4-Jan-2025

Summary

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Official Symbol
TotAprovided by FlyBase
Official Full Name
Turandot Aprovided by FlyBase
Primary source
FLYBASE:FBgn0028396
Locus tag
Dmel_CG31509
See related
AllianceGenome:FB:FBgn0028396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG31509; DIM 31; Dmel\CG31509; tot; Tot; Tot A; Tot-A; totA; Turt
Summary
Involved in several processes, including cellular response to mechanical stimulus; response to methylmercury; and response to water deprivation. Located in extracellular space. Is expressed in adult head. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See TotA in Genome Data Viewer
Location:
93A2-93A2; 3-69 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20871036..20871700)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16696758..16697422)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 93a Neighboring gene mir-1011 stem loop Neighboring gene Kainate-type ionotropic glutamate receptor subunit 1D Neighboring gene Turandot C Neighboring gene Turandot B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylmercury tolerance is associated with the humoral stress factor gene Turandot A. Mahapatra CT, et al. Neurotoxicol Teratol, 2012 Jul. PMID 22546818, Free PMC Article
  2. A humoral stress response in Drosophila. Ekengren S, et al. Curr Biol, 2001 Sep 18. PMID 11566110
  3. Expression of chronic myeloid leukemia oncogenes BCR-ABL (P210) and BCR-ABL (T315I) affect cellular and humoral innate immunity in Drosophila melanogaster. Abubaker D, et al. MicroPubl Biol, 2022. PMID 35622506, Free PMC Article
  4. Parallel gene expression evolution in natural and laboratory evolved populations. Hsu SK, et al. Mol Ecol, 2021 Feb. PMID 32979867, Free PMC Article
  5. Endosymbiont-based immunity in Drosophila melanogaster against parasitic nematode infection. Yadav S, et al. PLoS One, 2018. PMID 29466376, Free PMC Article

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Whole genome transcript profiling of developing larval brains of MeHg-tolerant and non-tolerant flies has identified Turandot A (TotA) as a potential MeHg tolerance gene.
    Title: Methylmercury tolerance is associated with the humoral stress factor gene Turandot A.
  2. The tota genes show a complex regulation pattern including signals from both the JAK-STAT and Imd pathways and Mekk1.
    Title: The MAPKKK Mekk1 regulates the expression of Turandot stress genes in response to septic injury in Drosophila.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellular response to UV IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to UV IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium HEP PubMed 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to mechanical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to mercury ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to methylmercury IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
turandot A
Names
CG31509-PA
Stress-inducible humoral factor turandot A
TotA-PA
Turandot-A
turandot

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    20871036..20871700
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080517.3 → NP_536778.2  turandot A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536778.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IN44, Q95NS3
    UniProtKB/TrEMBL
    A0A1B2AIV9
    Related
    FBpp0083378
    Conserved Domains (1) summary
    pfam07240
    Location:41 → 117
    Turandot; Stress-inducible humoral factor Turandot
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IN44.1 Q8IN44

Gene LinkOut

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