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Rgl Ral guanine nucleotide dissociation stimulator-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44115, updated on 4-Jan-2025

Summary

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Official Symbol
Rglprovided by FlyBase
Official Full Name
Ral guanine nucleotide dissociation stimulator-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0026376
Locus tag
Dmel_CG8865
See related
AllianceGenome:FB:FBgn0026376
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8865; Dmel\CG8865; dRGL; DRgl; RalGDS; RasGDS; rgl
Summary
Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in positive regulation of epidermal growth factor receptor signaling pathway and positive regulation of stem cell proliferation. Predicted to be active in plasma membrane. Is expressed in organism. Orthologous to several human genes including RGL1 (ral guanine nucleotide dissociation stimulator like 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Rgl in Genome Data Viewer
Location:
70C5-70C5; 3-41 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13906897..13925335, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13899997..13918435, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene dyschronic Neighboring gene uncharacterized protein Neighboring gene Dynactin 1, p150 subunit Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Quantitative trait loci for aggressive behavior in Drosophila melanogaster. Edwards AC, et al. Genetics, 2009 Jul. PMID 19414563, Free PMC Article
  2. The Rap1-Rgl-Ral signaling network regulates neuroblast cortical polarity and spindle orientation. Carmena A, et al. J Cell Biol, 2011 Nov 14. PMID 22084305, Free PMC Article
  3. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. van Dam TJ, et al. Cell Signal, 2009 Nov. PMID 19567266
  4. Differential efficacy of genetically swapping GAL4. Chen YJ, et al. J Neurogenet, 2019 Mar-Jun. PMID 30939963
  5. Using Drosophila melanogaster as a Model for Genotoxic Chemical Mutational Studies with a New Program, SnpSift. Cingolani P, et al. Front Genet, 2012. PMID 22435069, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of epidermal growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IC
Inferred by Curator
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ral guanine nucleotide dissociation stimulator-like
Names
CG8865-PA
CG8865-PB
CG8865-PC
CG8865-PD
CG8865-PE
Ral guanine nucleotide dissociation stimulator-like ortholog
Ral guanine nucleotide exchange factor
Ral guanine nucleotide exchange factor 2
Rgl-PA
Rgl-PB
Rgl-PC
Rgl-PD
Rgl-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13906897..13925335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_176327.2 → NP_788505.1  Ral guanine nucleotide dissociation stimulator-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788505.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BI2, Q9GR11
    Related
    FBpp0075537
    Conserved Domains (3) summary
    cd06224
    Location:66 → 198
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:678 → 766
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:274 → 539
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  2. NM_176325.2 → NP_788503.1  Ral guanine nucleotide dissociation stimulator-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788503.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BI2, Q9GR11
    Related
    FBpp0075536
    Conserved Domains (3) summary
    cd06224
    Location:66 → 198
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:678 → 766
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:274 → 539
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  3. NM_176326.2 → NP_788504.1  Ral guanine nucleotide dissociation stimulator-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788504.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86BI2, Q9GR11
    Related
    FBpp0075538
    Conserved Domains (3) summary
    cd06224
    Location:66 → 198
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:678 → 766
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:274 → 539
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  4. NM_079958.3 → NP_524697.1  Ral guanine nucleotide dissociation stimulator-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524697.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GR11, Q9U4U5, Q9VU99
    Related
    FBpp0075535
    Conserved Domains (3) summary
    cd06224
    Location:246 → 378
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:858 → 946
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:454 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

  5. NM_001274885.1 → NP_001261814.1  Ral guanine nucleotide dissociation stimulator-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCE9
    Conserved Domains (3) summary
    cd06224
    Location:246 → 378
    REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    cd00153
    Location:858 → 946
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:454 → 719
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCE9 M9PCE9
Q86BI2 Q86BI2
Q9GR11 Q9GR11
Q9U4U5 Q9U4U5

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