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Pten - Phosphatase and tensin homolog

Enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity and protein serine/threonine phosphatase activity. Involved in several processes, including negative regulation of hemocyte differentiation; negative regulation of signal transduction; and regulation of neuron projection development. Located in endosome membrane. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; medullary zone of lymph gland primary lobe; and organism. Used to study cancer and disease of metabolism. Human ortholog(s) of this gene implicated in several diseases, including PTEN hamartoma tumor syndrome (multiple); breast cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human PTEN (phosphatase and tensin homolog). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Pten

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Species Gene Architecture aa