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Septin5 Septin 5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43990, updated on 9-Dec-2024

Summary

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Official Symbol
Septin5provided by FlyBase
Official Full Name
Septin 5provided by FlyBase
Primary source
FLYBASE:FBgn0026361
Locus tag
Dmel_CG2916
See related
AllianceGenome:FB:FBgn0026361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2916; Dmel\CG2916; dSEPT5; Sep; sep5; Sep5
Summary
Predicted to enable GTPase activity and molecular adaptor activity. Involved in imaginal disc-derived wing morphogenesis and regulation of cell cycle. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in several structures, including anterior endoderm; dorsal ectoderm anlage; endoderm anlage; foregut anlage; and mesoderm. Orthologous to human SEPTIN10 (septin 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Septin5 in Genome Data Viewer
Location:
43F8-43F8; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7960133..7961921, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3847638..3849426, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ahuizotl Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene spenito Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis. O'Neill RS, et al. Genome, 2013 Dec. PMID 24433211
  2. Conservation and divergence of the G-interfaces of Drosophila melanogaster septins. de Freitas Fernandes A, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36576069
  3. Septins From Protists to People. Shuman B, et al. Front Cell Dev Biol, 2021. PMID 35111763, Free PMC Article
  4. Septins regulate the contractility of the actomyosin ring to enable adherens junction remodeling during cytokinesis of epithelial cells. Founounou N, et al. Dev Cell, 2013 Feb 11. PMID 23410939
  5. Evolution of three parent genes and their retrogene copies in Drosophila species. O'Neill RS, et al. Int J Evol Biol, 2013. PMID 23841016, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It has been found that Sep2 is uniquely required for follicle cell encapsulation of female germline cysts, and that Sep2 and Sep5 are redundant for follicle cell proliferation.
    Title: Partial Functional Diversification of Drosophila melanogaster Septin Genes Sep2 and Sep5.
  2. Results show that Sep2 Sep5 double mutants have an early pupal lethal phenotype and lack imaginal discs, suggesting that these genes have redundant functions during imaginal cell proliferation.
    Title: The Drosophila melanogaster septin gene Sep2 has a redundant function with the retrogene Sep5 in imaginal cell proliferation but is essential for oogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytoskeleton-dependent cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in imaginal disc development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cell cycle IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell division site IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of septin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in septin ring IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
septin 5
Names
CG2916-PA
CG2916-PB
Sep5
Septin-5
Septin5-PA
Septin5-PB
septin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7960133..7961921 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143704.3 → NP_651961.1  septin 5, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651961.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAA7, Q7KLG8
    Related
    FBpp0087952
    Conserved Domains (3) summary
    cd01850
    Location:43 → 311
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 394
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl12013
    Location:252 → 405
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. NM_165578.3 → NP_724632.1  septin 5, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724632.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAA7, Q7KLG8
    Related
    FBpp0087953
    Conserved Domains (3) summary
    cd01850
    Location:43 → 311
    CDC_Septin; CDC/Septin GTPase family
    COG5019
    Location:25 → 394
    CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cl12013
    Location:252 → 405
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KLG8 Q7KLG8

Gene LinkOut

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