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DIP1 DISCO Interacting Protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43981, updated on 9-Dec-2024

Summary

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Official Symbol
DIP1provided by FlyBase
Official Full Name
DISCO Interacting Protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0024807
Locus tag
Dmel_CG17686
See related
AllianceGenome:FB:FBgn0024807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17686; clot 10495; clot 2020; dip1; dip1a; Dmel\CG17686; klt; TO34; TO67; UbxBP1
Summary
Enables RNA binding activity. Involved in RNA catabolic process; germ-line stem-cell niche homeostasis; and response to virus. Located in cytoplasm and nucleus. Is active in nuclear body. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See DIP1 in Genome Data Viewer
Location:
20A4-20A5; 1-66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21624796..21630148, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21495823..21501175, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44712 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene flamenco

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Characteristics of the structural organization of the DIP1 gene in Drosophila melanogaster strains mutant for the flamenco gene]. Nefedova LN, et al. Genetika, 2007 Jan. PMID 17333941
  2. [Analysis of the structure and expression of the DIP1 gene in Drosophila melanogaster strains mutant for the flamenco gene]. Nefedova LN, et al. Genetika, 2009 Feb. PMID 19334614
  3. Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein. Bondos SE, et al. J Biol Chem, 2004 Jun 18. PMID 15039447
  4. High affinity, dsRNA binding by disconnected interacting protein 1. Catanese DJ Jr, et al. Biochem Biophys Res Commun, 2010 Aug 20. PMID 20643095, Free PMC Article
  5. [Analysis of the chromocenter DNA composition in polytene chromosomes of Drosophila orena ovarian nurse cells]. Usov KE, et al. Genetika, 2011 Apr. PMID 21675236

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the pre-mRNA destabilization caused by Dsn depletion is rescued in DIP1 or Sumo heterozygous mutants, suggesting that Dsn is a negative regulator of DIP1. Our results reveal that under normal circumstances nascent transcripts are susceptible to DIP1-mediated degradation, however intronic sequences are protected by Dsn until intron excision has taken place
    Title: SON protects nascent transcripts from unproductive degradation by counteracting DIP1.
  2. The RNA binding protein DIP1 regulates sisRNAs in Drosophila, which is necessary for germline stem cell homeostasis.
    Title: DIP1 modulates stem cell homeostasis in Drosophila through regulation of sisR-1.
  3. demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo
    Title: DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster.
  4. DIP1-c was shown to interact with ADAT, a tRNA deaminase that presumably modifies pre-tRNAs.
    Title: Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT.
  5. the longest isoform of this protein, DIP1-c, exhibits a 500-fold preference for dsRNA over dsDNA of similar nucleotide sequence.
    Title: High affinity, dsRNA binding by disconnected interacting protein 1.
  6. Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
    Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].
  7. the flamenco- phenotype may be associated with an alteration of DIP1 gene transcription, as in differentflamenco- strains the DIP1 gene expression is changed differently.
    Title: [Analysis of the structure and expression of the DIP1 gene in Drosophila melanogaster strains mutant for the flamenco gene].
  8. L27a protein, via interaction with DIP1, could be involved in protein synthesis as well as in cell cycle regulation
    Title: Identification of a cDNA clone encoding DIP1-binding protein in Drosophila melanogaster.
  9. disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development.
    Title: A novel double-stranded RNA-binding protein, disco interacting protein 1 (DIP1), contributes to cell fate decisions during Drosophila development.
  10. Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein
    Title: Hox transcription factor ultrabithorax Ib physically and genetically interacts with disconnected interacting protein 1, a double-stranded RNA-binding protein.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables double-stranded RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lncRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA intronic binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pre-miRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables siRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lncRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pre-mRNA catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of regulatory ncRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in siRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RISC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of RISC-loading complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nuclear body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DISCO interacting protein 1
Names
CG17686-PB
CG17686-PC
CG17686-PD
CG17686-PE
CG17686-PF
CG17686-PG
CG17686-PH
CG17686-PI
DIP1-PB
DIP1-PC
DIP1-PD
DIP1-PE
DIP1-PF
DIP1-PG
DIP1-PH
DIP1-PI
Disco-interacting protein 1
Disconnected-interacting protein 1
disconnected interacting protein 1
klett
ultrabithorax binding protein 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    21624796..21630148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169345.2 → NP_001162816.1  DISCO interacting protein 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162816.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NIH3, Q9TW12
    Conserved Domains (1) summary
    cd00048
    Location:71 → 130
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  2. NM_079929.3 → NP_524668.2  DISCO interacting protein 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524668.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U4F5, Q9U6N4
    Related
    FBpp0077064
    Conserved Domains (1) summary
    cd00048
    Location:157 → 216
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  3. NM_167772.2 → NP_728449.1  DISCO interacting protein 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728449.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NHW9, Q9TW27
    Related
    FBpp0077065
    Conserved Domains (1) summary
    cd00048
    Location:172 → 231
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  4. NM_001169346.2 → NP_001162817.1  DISCO interacting protein 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162817.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRC7, Q9NIH3
    Conserved Domains (1) summary
    cd00048
    Location:140 → 199
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  5. NM_167774.3 → NP_728451.2  DISCO interacting protein 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728451.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GNA3, Q9W5S7
    Conserved Domains (1) summary
    cd00048
    Location:156 → 215
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  6. NM_167773.3 → NP_728450.1  DISCO interacting protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728450.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V4V2, Q9GND0
    Related
    FBpp0077063
    Conserved Domains (1) summary
    cd00048
    Location:171 → 230
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  7. NM_001169343.2 → NP_001162814.1  DISCO interacting protein 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRC7, Q9NIH3
    Conserved Domains (1) summary
    cd00048
    Location:140 → 199
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...

  8. NM_001169344.2 → NP_001162815.1  DISCO interacting protein 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162815.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MRC7, Q9NIH3
    Conserved Domains (1) summary
    cd00048
    Location:140 → 199
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V4V2 A4V4V2
Q86LT0 Q86LT0
Q8MRC7 Q8MRC7
Q9GNA3 Q9GNA3
Q9GNA6 Q9GNA6
Q9GND0 Q9GND0
Q9GNJ2 Q9GNJ2
Q9NHW9 Q9NHW9
Q9NIH3 Q9NIH3
Q9TW12 Q9TW12
Q9TW27 Q9TW27
Q9U4F5 Q9U4F5
Q9U6N4 Q9U6N4
Q9W5S7 Q9W5S7

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