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Lip2 Lipase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43980, updated on 4-Jan-2025

Summary

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Official Symbol
Lip2provided by FlyBase
Official Full Name
Lipase 2provided by FlyBase
Primary source
FLYBASE:FBgn0024740
Locus tag
Dmel_CG17116
See related
AllianceGenome:FB:FBgn0024740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17116; dilp2; DILP2; Dmel\CG17116; Dmlip2; lip2
Summary
Predicted to enable triacylglycerol lipase activity. Predicted to be involved in lipid metabolic process. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; and cholesterol ester storage disease. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPJ (lipase family member J). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Lip2 in Genome Data Viewer
Location:
32A4-32A5; 2-43 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10701940..10709453, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10701940..10709453, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44181 Neighboring gene uncharacterized protein Neighboring gene Lipase 1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44407 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila melanogaster lipase homologs: a gene family with tissue and developmental specific expression. Pistillo D, et al. J Mol Biol, 1998 Mar 13. PMID 9566193
  2. Suppression of intestinal dysfunction in a Drosophila model of Parkinson's disease is neuroprotective. Fedele G, et al. Nat Aging, 2022 Apr. PMID 37117744
  3. Female sterile mutations and egg chamber development in Drosophila melanogaster. Gigliotti S, et al. Int J Dev Biol, 2000. PMID 11061421
  4. Insulin/insulin-like growth factor-1 signalling (IIS) based regulation of lifespan across species. Mathew R, et al. Biogerontology, 2017 Feb. PMID 28101820
  5. Genetic architecture of natural variation in cuticular hydrocarbon composition in Drosophila melanogaster. Dembeck LM, et al. Elife, 2015 Nov 14. PMID 26568309, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lipase 2
Names
CG17116-PA
CG17116-PB
Lip2-PA
Lip2-PB
NP_001285812.1
NP_524667.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10701940..10709453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298883.1 → NP_001285812.1  lipase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285812.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2J9C9
    Conserved Domains (2) summary
    pfam00561
    Location:35 → 345
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:12 → 54
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region

  2. NM_079928.2 → NP_524667.1  lipase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKR5
    Related
    FBpp0079712
    Conserved Domains (2) summary
    PLN02872
    Location:24 → 407
    PLN02872; triacylglycerol lipase
    pfam04083
    Location:48 → 90
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKR5 Q9VKR5
X2J9C9 X2J9C9

Gene LinkOut

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