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MED20 Mediator complex subunit 20 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43952, updated on 4-Jan-2025

Summary

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Official Symbol
MED20provided by FlyBase
Official Full Name
Mediator complex subunit 20provided by FlyBase
Primary source
FLYBASE:FBgn0013531
Locus tag
Dmel_CG18780
See related
AllianceGenome:FB:FBgn0013531
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18267; CG18780; Dmel\CG18780; dTrap26; dTrfp; l(2)28DE; med20; Med20; p29; Srb2/TRFP; Tmr; Trfp; TrfP
Summary
Contributes to transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleus. Part of mediator complex. Is expressed in spermatocyte and testis. Orthologous to human MED20 (mediator complex subunit 20). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See MED20 in Genome Data Viewer
Location:
28E1-28E1; 2-30 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8071812..8072848, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8071812..8072848, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ribosomal protein L36A Neighboring gene Multiple EGF like domains 8 Neighboring gene purity of essence Neighboring gene TBP-related factor Neighboring gene Macroglobulin complement-related Neighboring gene antisense RNA:CR45257

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Diadenosine 5",5"'P1,P4-tetraphosphatase in Drosophila embryos: developmental regulation and characterization. Vallejo CG, et al. Int J Biochem, 1989. PMID 2558922
  2. A new factor related to TATA-binding protein has highly restricted expression patterns in Drosophila. Crowley TE, et al. Nature, 1993 Feb 11. PMID 8429912
  3. Control of Drosophila perineurial glial growth by interacting neurotransmitter-mediated signaling pathways. Yager J, et al. Proc Natl Acad Sci U S A, 2001 Aug 28. PMID 11517334, Free PMC Article
  4. Defining the essential function of FBP/KSRP proteins: Drosophila Psi interacts with the mediator complex to modulate MYC transcription and tissue growth. Guo L, et al. Nucleic Acids Res, 2016 Sep 19. PMID 27207882, Free PMC Article
  5. Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity. Park J, et al. Elife, 2019 Jun 21. PMID 31223115, Free PMC Article

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mediator complex subunit 20
Names
CG18780-PA
CG18780-PB
MED20-PA
MED20-PB
Trf-proximal
lethal(2)28DE
mediator
transcription mediator-related

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    8071812..8072848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079924.3 → NP_524663.2  mediator complex subunit 20, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524663.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91641, Q9VLT4
    Related
    FBpp0079166
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 215
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex

  2. NM_001273294.1 → NP_001260223.1  mediator complex subunit 20, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260223.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCC3
    Conserved Domains (1) summary
    pfam08612
    Location:1 → 215
    Med20; TATA-binding related factor (TRF) of subunit 20 of Mediator complex
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCC3 M9PCC3
P91641.2 P91641

Gene LinkOut

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