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wb wing blister [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43946, updated on 9-Dec-2024

Summary

Official Symbol
wbprovided by FlyBase
Official Full Name
wing blisterprovided by FlyBase
Primary source
FLYBASE:FBgn0261563
Locus tag
Dmel_CG42677
See related
AllianceGenome:FB:FBgn0261563
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
2; 2Lan; 2]]; A1; alpha1; alpha[[1; BEST:CK02229; BG:DS03792.1; BG:DS03792.2; CG15288; CG32970; CG42677; CK02229; CT35236; DLAM; Dmel\CG42677; fus5; l(2)09437; l(2)34Fb; l(2)br1; l34Fb; LanA1; LanWb; LM-A/alpha2; Wb
Old locus tag
Dmel_CG15288; Dmel_CG32970
Summary
Predicted to be an extracellular matrix structural constituent. Involved in digestive tract mesoderm development; epithelial structure maintenance; and gonad development. Located in basement membrane. Is expressed in several structures, including alary cell; border follicle cell; direct flight muscle precursor cell; female germline cell; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy; congenital merosin-deficient muscular dystrophy 1A; muscular dystrophy; and myopia. Orthologous to several human genes including LAMA1 (laminin subunit alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

Location:
35A3-35A4; 2-50 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (14263027..14328262)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (14263027..14328262)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44728 Neighboring gene long non-coding RNA:CR44216 Neighboring gene long non-coding RNA:CR44729 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43639 Neighboring gene long non-coding RNA:CR43640 Neighboring gene male sterile (2) 34Fe Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables extracellular matrix structural constituent IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in digestive tract mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
wing blister
Names
CG42677-PB
CG42677-PC
CG42677-PD
CG42677-PE
CG42677-PF
CG42677-PG
D-laminin alpha2
SGP cluster fusion defects 5
alpha laminin
laminin
laminin A2
laminin alpha1,2
laminin alpha[[1,2]]
lamininW
lethal 1 in the black-reduced region
lethal group A1
wb-PB
wb-PC
wb-PD
wb-PE
wb-PF
wb-PG
wing blistered
wingblister

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    14263027..14328262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165086.3NP_723870.1  wing blister, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IP51, Q9XZC9
    Related
    FBpp0291871
    Conserved Domains (11) summary
    pfam03302
    Location:9531414
    VSP; Giardia variant-specific surface protein
    COG0699
    Location:19332267
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:11501197
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:31923347
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam00052
    Location:14861611
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:11991247
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:164396
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam02210
    Location:28042944
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:22772400
    Laminin_II; Laminin Domain II
    cl22855
    Location:407507
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    cl22861
    Location:23992492
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  2. NM_057442.5NP_476790.3  wing blister, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476790.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XZC9, R9PY40
    Conserved Domains (8) summary
    COG0699
    Location:19332267
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:11501197
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    pfam00052
    Location:14861611
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:11991247
    Laminin_EGF; Laminin EGF domain
    pfam00055
    Location:164396
    Laminin_N; Laminin N-terminal (Domain VI)
    pfam02210
    Location:28042944
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:22772400
    Laminin_II; Laminin Domain II
    cl22861
    Location:23992492
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  3. NM_001201879.2NP_001188808.1  wing blister, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188808.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU0
    Conserved Domains (9) summary
    COG0699
    Location:11251459
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:342389
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:23842539
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl00348
    Location:11861277
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam00052
    Location:678803
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:391439
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:19962136
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:14691592
    Laminin_II; Laminin Domain II
    cl22861
    Location:15911684
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  4. NM_001201878.2NP_001188807.1  wing blister, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188807.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU0
    Conserved Domains (9) summary
    COG0699
    Location:11251459
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:342389
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:23842539
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl00348
    Location:11861277
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam00052
    Location:678803
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:391439
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:19962136
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:14691592
    Laminin_II; Laminin Domain II
    cl22861
    Location:15911684
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  5. NM_001201880.2NP_001188809.1  wing blister, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188809.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU0
    Conserved Domains (9) summary
    COG0699
    Location:11251459
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:342389
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:23842539
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl00348
    Location:11861277
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam00052
    Location:678803
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:391439
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:19962136
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:14691592
    Laminin_II; Laminin Domain II
    cl22861
    Location:15911684
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
  6. NM_001201877.2NP_001188806.1  wing blister, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188806.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MRU0
    Conserved Domains (9) summary
    COG0699
    Location:11251459
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd00055
    Location:342389
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:23842539
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cl00348
    Location:11861277
    GCD2; Translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]
    pfam00052
    Location:678803
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:391439
    Laminin_EGF; Laminin EGF domain
    pfam02210
    Location:19962136
    Laminin_G_2; Laminin G domain
    pfam06009
    Location:14691592
    Laminin_II; Laminin Domain II
    cl22861
    Location:15911684
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...