prc pericardin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: prcprovided by FlyBase
Official Full Name: pericardinprovided by FlyBase
Primary source: FLYBASE:FBgn0028573
Locus tag: Dmel_CG5700
See related: AllianceGenome:FB:FBgn0028573
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BEST:CK01593; CG5700; CK01593; Dmel\CG5700; EC11; pc; Pc; PC; Prc; PRC
Summary: An extracellular matrix structural constituent. Involved in basement membrane assembly; cell adhesion involved in heart morphogenesis; and larval heart development. Located in extracellular matrix. Part of collagen type IV trimer. Is expressed in several structures, including CNS glial cell; adult head; adult heart; dorsal vessel wall cell; and pericardial cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (11958872..11966131, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (11951972..11959231, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

results support the function of a collagen-like protein in the coordinated migration of dorsal ectoderm and heart cells
Title: Pericardin, a Drosophila type IV collagen-like protein is involved in the morphogenesis and maintenance of the heart epithelium during dorsal ectoderm closure.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in basement membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion involved in heart morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart development	TAS Traceable Author Statement more info	PubMed
involved_in larval heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in larval heart development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of collagen type IV trimer	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed

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