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amx almondex [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43869, updated on 9-Dec-2024

Summary

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Official Symbol
amxprovided by FlyBase
Official Full Name
almondexprovided by FlyBase
Primary source
FLYBASE:FBgn0000077
Locus tag
Dmel_CG12127
See related
AllianceGenome:FB:FBgn0000077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH02974; CG12127; Dmel\CG12127; fs(1)amx
Summary
Involved in several processes, including cell fate determination; lateral inhibition; and positive regulation of Notch signaling pathway. Predicted to be located in plasma membrane. Is expressed in organism. Used to study Alzheimer's disease. Orthologous to human TM2D3 (TM2 domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See amx in Genome Data Viewer
Location:
8D2-8D2; 1-27 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9245915..9247336, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (9139948..9141369, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 8a Neighboring gene mir-4916 stem loop Neighboring gene multi sex combs Neighboring gene La related protein 7 Neighboring gene Downstream of raf1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila. Yang SA, et al. Methods Mol Biol, 2022. PMID 35674905, Free PMC Article
  2. The development of eggs produced by the female-sterile mutant almondex of Drosophila melanogaster. Shannon MP. J Exp Zool, 1973 Mar. PMID 4633255
  3. Characterization of the female-sterile mutant almondex of Drosophila melanogaster. Shannon MP. Genetica, 1972. PMID 4625164
  4. A cytogenetic analysis of the lozenge pseudoalleles in Drosophila. GREEN MM, et al. Z Indukt Abstamm Vererbungsl, 1956. PMID 13478080
  5. Partial rescue of embryos from two maternal-effect neurogenic mutants by transplantation of wild-type ooplasm. LaBonne SG, et al. Dev Biol, 1985 Jul. PMID 4007265

See all (60) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TM2D genes regulate Notch signaling and neuronal function in Drosophila.
    Title: TM2D genes regulate Notch signaling and neuronal function in Drosophila.
  2. Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.
    Title: Maternal almondex, a neurogenic gene, is required for proper subcellular Notch distribution in early Drosophila embryogenesis.
  3. we found that human TM2D3 expressed under the control of endogenous Drosophila amx regulatory elements is capable of rescuing the embryonic neurogenic phenotype, indicating that Amx and TM2D3 are orthologs and have conserved molecular functions in vivo
    Title: Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease.
  4. Our molecular data reveal that amx is ubiquitously expressed and encodes a conserved putative transmembrane protein, composed of several domains that are differently required for amx function in the fly.
    Title: Implication of the Drosophila beta-amyloid peptide binding-like protein AMX in Notch signaling during early neurogenesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in ectodermal cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lateral inhibition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lateral inhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mesoderm development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
almondex
Names
CG12127-PA
CG12127-PB
amx-PA
amx-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9245915..9247336 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079905.3 → NP_524644.1  almondex, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524644.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U4H5, Q9W361
    UniProtKB/TrEMBL
    M9NF00
    Related
    FBpp0071266
    Conserved Domains (1) summary
    pfam05154
    Location:219 → 268
    TM2; TM2 domain

  2. NM_001258662.2 → NP_001245591.1  almondex, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245591.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9U4H5, Q9W361
    UniProtKB/TrEMBL
    M9NF00
    Conserved Domains (1) summary
    pfam05154
    Location:219 → 268
    TM2; TM2 domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NF00 M9NF00
Q9U4H5.1 Q9U4H5

Gene LinkOut

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