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HnRNP-K Heterogeneous nuclear ribonucleoprotein K [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43862, updated on 4-Jan-2025

Summary

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Official Symbol
HnRNP-Kprovided by FlyBase
Official Full Name
Heterogeneous nuclear ribonucleoprotein Kprovided by FlyBase
Primary source
FLYBASE:FBgn0267791
Locus tag
Dmel_CG13425
See related
AllianceGenome:FB:FBgn0267791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bancal; bl; Bl; BL; CG13425; dhnRNP K; Dmel\CG13425; hnRNP K; hnRNP-A1L; hrb57a; Hrb57A; l(2)k08305; Q18
Summary
Predicted to enable mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome. Located in chromatin and omega speckle. Is expressed in several structures, including adult brain cell body rind; adult head; cardiogenic mesoderm; epithelium; and germline cell. Human ortholog(s) of this gene implicated in Raynaud disease. Orthologous to human HNRNPK (heterogeneous nuclear ribonucleoprotein K). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See HnRNP-K in Genome Data Viewer
Location:
57A6-57A7; 2-91 cM
Exon count:
12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (20587551..20606854)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16475056..16494359)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mir-992 stem loop Neighboring gene Nnf1a Neighboring gene mir-7 stem loop Neighboring gene Hillarin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The dynamic nuclear redistribution of an hnRNP K-homologous protein during Drosophila embryo development and heat shock. Flexibility of transcription sites in vivo. Buchenau P, et al. J Cell Biol, 1997 Apr 21. PMID 9128243, Free PMC Article
  2. Cell nucleus: chromosome dynamics in nuclei of living cells. Zink D, et al. Curr Biol, 1998 Apr 23. PMID 9560332
  3. Visualizing chromatin dynamics in interphase nuclei. Gasser SM. Science, 2002 May 24. PMID 12029120
  4. Chriz, a chromodomain protein specific for the interbands of Drosophila melanogaster polytene chromosomes. Gortchakov AA, et al. Chromosoma, 2005 May. PMID 15821938
  5. The distribution of polycomb-group proteins during cell division and development in Drosophila embryos: impact on models for silencing. Buchenau P, et al. J Cell Biol, 1998 Apr 20. PMID 9548724, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that the hsromega transcripts regulate cellular levels of DIAP1 via the hnRNP Hrb57A, which physically interacts with DIAP1.
    Title: The developmentally active and stress-inducible noncoding hsromega gene is a novel regulator of apoptosis in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
located_in omega speckle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein K
Names
CG13425-PA
CG13425-PB
CG13425-PC
CG13425-PD
CG13425-PE
CG13425-PF
HnRNP-K-PA
HnRNP-K-PB
HnRNP-K-PC
HnRNP-K-PD
HnRNP-K-PE
HnRNP-K-PF
bancal
bancal hnRNP
heterogeneous nuclear ribonucleoprotein at 57A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    20587551..20606854
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206184.2 → NP_995906.1  heterogeneous nuclear ribonucleoprotein K, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBW0, Q7KA80
    Conserved Domains (1) summary
    cd02396
    Location:103 → 167
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  2. NM_001169745.2 → NP_001163216.1  heterogeneous nuclear ribonucleoprotein K, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163216.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGN7, Q7KA80
    Conserved Domains (1) summary
    cd02396
    Location:97 → 161
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  3. NM_206185.2 → NP_995907.1  heterogeneous nuclear ribonucleoprotein K, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995907.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBW1, Q7KA80
    Conserved Domains (1) summary
    cd02396
    Location:97 → 161
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  4. NM_145883.3 → NP_665890.2  heterogeneous nuclear ribonucleoprotein K, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_665890.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBW3, D3DMD1
    Related
    FBpp0085537
    Conserved Domains (2) summary
    cd00105
    Location:339 → 402
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:14 → 78
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  5. NM_001274173.1 → NP_001261102.1  heterogeneous nuclear ribonucleoprotein K, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261102.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBW1, Q7KA80
    Conserved Domains (1) summary
    cd02396
    Location:97 → 161
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...

  6. NM_206183.3 → NP_995905.1  heterogeneous nuclear ribonucleoprotein K, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995905.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZBW4, Q8IGP8
    Conserved Domains (1) summary
    cd00105
    Location:244 → 307
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1ZBW0 A1ZBW0
A1ZBW1 A1ZBW1
A1ZBW3 A1ZBW3
A1ZBW4 A1ZBW4
E1JGN7 E1JGN7
Q7KA80 Q7KA80
Q7KHL0 Q7KHL0
Q8IGP8 Q8IGP8
Q8SZZ6 Q8SZZ6
Q9V948 Q9V948

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