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Actbeta Activin-beta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43826, updated on 4-Jan-2025

Summary

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Official Symbol
Actbetaprovided by FlyBase
Official Full Name
Activin-betaprovided by FlyBase
Primary source
FLYBASE:FBgn0024913
Locus tag
Dmel_CG11062
See related
AllianceGenome:FB:FBgn0024913
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
act; Act; Act-beta; ACTB; actbeta; activin; Activin; activin-beta; anon-WO02059370.79; beta-Activin; CG11062; dact; dAct; dACT; dActbeta; dActivin; Dmel\CG11062
Summary
Predicted to enable cytokine activity. Involved in several processes, including nervous system development; positive regulation of imaginal disc growth; and positive regulation of neuroblast proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including epithelial cell; ganglia; inner photoreceptor cell; male germline cell; and presumptive embryonic/larval system. Orthologous to several human genes including INHBA (inhibin subunit beta A); INHBB (inhibin subunit beta B); and INHBC (inhibin subunit beta C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Actbeta in Genome Data Viewer
Location:
102F8-102F8; 4-0 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (1077331..1084796, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (1097957..1105422, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene Calcium/calmodulin-dependent protein kinase II Neighboring gene apolipophorin Neighboring gene Zyxin Neighboring gene shaven Neighboring gene Calsyntenin Neighboring gene ADP ribosylation factor 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of Drosophila activin and follistatin cDNAs using novel MACH amplification protocols. Haerry TE, et al. Gene, 2002 May 29. PMID 12095682
  2. Identification of a new member of transforming growth factor-beta superfamily in Drosophila: the first invertebrate activin gene. Kutty G, et al. Biochem Biophys Res Commun, 1998 May 29. PMID 9618266
  3. Drosophila activins adapt gut size to food intake and promote regenerative growth. Christensen CF, et al. Nat Commun, 2024 Jan 4. PMID 38177201, Free PMC Article
  4. Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster. Moss-Taylor L, et al. Genetics, 2019 Dec. PMID 31585954, Free PMC Article
  5. Integrative analysis reveals a conserved role for the amyloid precursor protein in proteostasis during aging. Nithianandam V, et al. Nat Commun, 2023 Nov 3. PMID 37923712, Free PMC Article

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Activin is a neural inducer of a male-specific muscle in Drosophila.
    Title: Activin is a neural inducer of a male-specific muscle in Drosophila.
  2. TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
    Title: TGFB-INHB/activin signaling regulates age-dependent autophagy and cardiac health through inhibition of MTORC2.
  3. Actbeta is a positive regulator of muscle mass that is directly delivered to muscles by motoneurons.
    Title: Body Size and Tissue-Scaling Is Regulated by Motoneuron-Derived Activinß in Drosophila melanogaster.
  4. The authors find that both arms of the TFGb signaling pathways specifically instruct the pale photoreceptor subset in R8. The Activin arm utilizes the three ligands dActb, Daw, and Myo non-redundantly to activate Babo and downstream dSmad2 in R8, while the BMP arm signals by way of Dpp and Gbb to Tkv and Mad.
    Title: Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.
  5. a conserved role for activin in enhancing adipokinetic hormone/glucagon signaling and glycemic control, is reported.
    Title: Midgut-Derived Activin Regulates Glucagon-like Action in the Fat Body and Glycemic Control.
  6. Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction
    Title: Anterograde Activin signaling regulates postsynaptic membrane potential and GluRIIA/B abundance at the Drosophila neuromuscular junction.
  7. These data reveal how insulin signaling can regulate aging through control of Activin signaling that in turn controls autophagy, representing a potentially conserved molecular basis for longevity assurance
    Title: Activin signaling targeted by insulin/dFOXO regulates aging and muscle proteostasis in Drosophila.
  8. These results suggest that the Activin signaling pathway is required for producing the proper number of neurons to enable normal connection of incoming photoreceptor axons to their targets.
    Title: Drosophila Activin- and the Activin-like product Dawdle function redundantly to regulate proliferation in the larval brain.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in R8 cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in activin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in activin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of positive regulation of glycogen catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of imaginal disc-derived wing size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Activin-beta
Names
Actbeta-PA
CG11062-PA
DmActivin-beta
activan
activin
activin 102F
activin beta
activin-b
activinbeta
dActivin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    1077331..1084796 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143685.3 → NP_651942.2  Activin-beta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651942.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O61643, Q8MRB1, Q8WR60, Q9V497
    Related
    FBpp0088273
    Conserved Domains (2) summary
    pfam00019
    Location:843 → 945
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:370 → 509
    TGFb_propeptide; TGF-beta propeptide
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O61643.2 O61643

Gene LinkOut

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