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bt bent [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43814, updated on 4-Jan-2025

Summary

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Official Symbol
btprovided by FlyBase
Official Full Name
bentprovided by FlyBase
Primary source
FLYBASE:FBgn0005666
Locus tag
Dmel_CG32019
See related
AllianceGenome:FB:FBgn0005666
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
39c-18; Bt; CG10285; CG1479; CG32019; CT3598; CT8086; Dmel\CG32019; l(2)2; l(2)23; l(4)102CDa; l(4)2; l(4)21; l(4)23; l(4)37; l(4)38; l(4)PT-2; Prj; projectin; titin
Summary
Enables protein kinase activity. A structural constituent of muscle. Involved in mesoderm development; muscle thin filament assembly; and sarcomere organization. Located in Z disc. Is expressed in several structures, including adult head; adult heart; border follicle cell; muscle cell; and muscle system. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and myopathy (multiple). Orthologous to several human genes including TTN (titin). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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Location:
102D5-102E1; 4-0 cM
Exon count:
49
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (724400..776474)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (745026..797100)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene myoglianin Neighboring gene eyeless Neighboring gene long non-coding RNA:CR45200 Neighboring gene Mediator complex subunit 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila projectin: relatedness to titin and twitchin and correlation with lethal(4) 102 CDa and bent-dominant mutants. Fyrberg CC, et al. Proc Biol Sci, 1992 Jul 22. PMID 1359548
  2. Autophosphorylating protein kinase activity in titin-like arthropod projectin. Maroto M, et al. J Mol Biol, 1992 Mar 20. PMID 1560453
  3. Structure of the Drosophila projectin protein: isoforms and implication for projectin filament assembly. Daley J, et al. J Mol Biol, 1998 May 29. PMID 9636710
  4. Role of the elastic protein projectin in stretch activation and work output of Drosophila flight muscles. Vigoreaux JO, et al. Adv Exp Med Biol, 2000. PMID 10987076
  5. Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains. Ayme-Southgate A, et al. J Cell Biol, 1995 Feb. PMID 7844153, Free PMC Article

See all (131) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Projectin immunolocalization studies during myofibrillogenesis in Drosophila indirect flight muscles.
    Title: Assembly of the giant protein projectin during myofibrillogenesis in Drosophila indirect flight muscles.
  2. isoforms and alternative splicing of PEVK-like region
    Title: Alternative splicing of an amino-terminal PEVK-like region generates multiple isoforms of Drosophila projectin.
  3. Projectin is oriented within the indirect flight muscles sarcomere with its NH2-terminus embedded in the Z-bands. This protein has an elastic region, possibly the PEVK-like domain located close to the NH2-terminus.
    Title: In indirect flight muscles Drosophila projectin has a short PEVK domain, and its NH2-terminus is embedded at the Z-band.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 729819-730256 mobile_element_type = transposon:INE-1{}1980
  • Loc: 749321-749642 mobile_element_type = transposon:INE-1{}2051
  • Loc: 749972-750190 mobile_element_type = transposon:INE-1{}2053
  • Loc: 751516-751635 mobile_element_type = transposon:INE-1{}2073
  • Loc: 757191-757463 mobile_element_type = transposon:INE-1{}2074
  • Loc: 773208-773805 mobile_element_type = transposon:Tc1{}1529

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables structural constituent of muscle IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mesoderm development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in muscle thin filament assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in I band IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in M band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bent
Names
C-protein
CG32019-PC
CG32019-PF
CG32019-PH
CG32019-PI
CG32019-PJ
bt-PC
bt-PF
bt-PH
bt-PI
bt-PJ
lethal(4) Powell, Tennessee-2
myosin LCK
projectin
projectin myosin light chain kinase
twitchin
NP_001162825.1
NP_001259071.1
NP_001259072.1
NP_001284716.1
NP_995598.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    724400..776474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272143.2 → NP_001259072.1  bent, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259072.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MN91
    Conserved Domains (10) summary
    cd00096
    Location:7205 → 7272
    Ig; Immunoglobulin domain
    cd05748
    Location:6115 → 6188
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:8579 → 8644
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:7922 → 8177
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:4922 → 5002
    IG; Immunoglobulin
    smart00410
    Location:1436 → 1521
    IG_like; Immunoglobulin like
    cd00063
    Location:6292 → 6384
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:8565 → 8654
    I-set; Immunoglobulin I-set domain
    cd14114
    Location:7919 → 8177
    STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
    cl11960
    Location:3449 → 3523
    Ig; Immunoglobulin domain

  2. NM_001169354.2 → NP_001162825.1  bent, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162825.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1YSG0
    Conserved Domains (10) summary
    cd00096
    Location:7272 → 7339
    Ig; Immunoglobulin domain
    cd05748
    Location:6182 → 6255
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:8646 → 8711
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:7989 → 8244
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:4989 → 5069
    IG; Immunoglobulin
    smart00410
    Location:1503 → 1588
    IG_like; Immunoglobulin like
    cd00063
    Location:6359 → 6451
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:8632 → 8721
    I-set; Immunoglobulin I-set domain
    cd14114
    Location:7986 → 8244
    STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
    cl11960
    Location:3516 → 3590
    Ig; Immunoglobulin domain

  3. NM_205876.3 → NP_995598.1  bent, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995598.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KQP6
    Conserved Domains (10) summary
    cd00096
    Location:6987 → 7054
    Ig; Immunoglobulin domain
    cd05748
    Location:5897 → 5970
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:8361 → 8426
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:7704 → 7959
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:4704 → 4784
    IG; Immunoglobulin
    smart00410
    Location:7069 → 7155
    IG_like; Immunoglobulin like
    cd00063
    Location:6074 → 6166
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:8347 → 8436
    I-set; Immunoglobulin I-set domain
    cd14114
    Location:7701 → 7959
    STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
    cl11960
    Location:3231 → 3305
    Ig; Immunoglobulin domain

  4. NM_001297787.1 → NP_001284716.1  bent, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X2JD89
    Conserved Domains (10) summary
    cd00096
    Location:6941 → 7008
    Ig; Immunoglobulin domain
    cd05748
    Location:5851 → 5924
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:8315 → 8380
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:7658 → 7913
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:4658 → 4738
    IG; Immunoglobulin
    smart00410
    Location:7023 → 7109
    IG_like; Immunoglobulin like
    cd00063
    Location:6028 → 6120
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:8301 → 8390
    I-set; Immunoglobulin I-set domain
    cd14114
    Location:7655 → 7913
    STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
    cl11960
    Location:3185 → 3259
    Ig; Immunoglobulin domain

  5. NM_001272142.1 → NP_001259071.1  bent, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259071.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MPZ1
    Conserved Domains (10) summary
    cd00096
    Location:6766 → 6833
    Ig; Immunoglobulin domain
    cd05748
    Location:5676 → 5749
    Ig_Titin_like; Immunoglobulin (Ig)-like domain of titin and similar proteins
    smart00408
    Location:8121 → 8186
    IGc2; Immunoglobulin C-2 Type
    smart00220
    Location:7483 → 7738
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    smart00409
    Location:4483 → 4563
    IG; Immunoglobulin
    smart00410
    Location:6848 → 6934
    IG_like; Immunoglobulin like
    cd00063
    Location:5853 → 5945
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:8107 → 8196
    I-set; Immunoglobulin I-set domain
    cd14114
    Location:7480 → 7738
    STKc_Twitchin_like; The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin
    cl11960
    Location:3010 → 3084
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D1YSG0 D1YSG0
L0MN91 L0MN91
L0MPZ1 L0MPZ1
O76280 O76280
O76281 O76281
Q24463 Q24463
Q7KQP6 Q7KQP6
Q8MZ51 Q8MZ51
Q8ST85 Q8ST85
Q961U1 Q961U1
X2JD89 X2JD89

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