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Gat GABA transporter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43805, updated on 4-Jan-2025

Summary

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Official Symbol
Gatprovided by FlyBase
Official Full Name
GABA transporterprovided by FlyBase
Primary source
FLYBASE:FBgn0039915
Locus tag
Dmel_CG1732
See related
AllianceGenome:FB:FBgn0039915
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0149848.11; CG1732; CG1732a; dGAT; Dmel\CG1732; DmGAT; gat; GAT
Summary
Predicted to enable gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in cellular response to mechanical stimulus. Located in glial cell projection and plasma membrane. Is expressed in several structures, including anterior-posterior subdivision of organism; brain; larval nervous system; larval ventral nerve cord; and optic lobe neuroepithelial cell. Human ortholog(s) of this gene implicated in alcohol dependence and myoclonic-atonic epilepsy. Orthologous to human SLC6A1 (solute carrier family 6 member 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Gat in Genome Data Viewer
Location:
102D1-102D1; 4-0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (629691..635350)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (650317..655976)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene maverick Neighboring gene mir-954 stem loop Neighboring gene pseudo Neighboring gene Eye-enriched kainate receptor Neighboring gene gawky

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GABA transporters in Drosophila melanogaster: molecular cloning, behavior, and physiology. Neckameyer WS, et al. Invert Neurosci, 1998 Mar. PMID 10212397
  2. Molecular and Clinical Repercussions of GABA Transporter 1 Variants Gone Amiss: Links to Epilepsy and Developmental Spectrum Disorders. Fischer FP, et al. Front Mol Biosci, 2022. PMID 35295842, Free PMC Article
  3. Microbiota alterations in proline metabolism impact depression. Mayneris-Perxachs J, et al. Cell Metab, 2022 May 3. PMID 35508109
  4. A pipeline for precise and efficient genome editing by sgRNA-Cas9 RNPs in Drosophila. Nyberg KG, et al. Fly (Austin), 2020 Mar-Dec. PMID 33016195, Free PMC Article
  5. Tet controls axon guidance in early brain development through glutamatergic signaling. Tran H, et al. iScience, 2024 May 17. PMID 38655199, Free PMC Article

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: 630665-630838 mobile_element_type = transposon:INE-1{}1920

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables gamma-aminobutyric acid:sodium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables gamma-aminobutyric acid:sodium:chloride symporter activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gamma-aminobutyric acid transport ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in glial cell projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISM
Inferred from Sequence Model
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
GABA transporter
Names
CG1732-PA
CG1732-PB
Gat-PA
Gat-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    629691..635350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143673.3 → NP_651930.2  GABA transporter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651930.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NND1, Q7YU42, Q9V4E7
    Related
    FBpp0088910
    Conserved Domains (1) summary
    cd11496
    Location:58 → 611
    SLC6sbd-TauT-like; Na(+)- and Cl(-)-dependent taurine transporter TauT, and related proteins; solute-binding domain

  2. NM_166779.4 → NP_726594.2  GABA transporter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726594.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMC1
    Related
    FBpp0088909
    Conserved Domains (1) summary
    cl00456
    Location:58 → 499
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IMC1 Q8IMC1
Q9V4E7 Q9V4E7

Gene LinkOut

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