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CG1909 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43800, updated on 4-Jan-2025

Summary

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Official Symbol
CG1909provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039911
Locus tag
Dmel_CG1909
See related
AllianceGenome:FB:FBgn0039911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1909
Summary
Predicted to enable acetylcholine receptor binding activity and zinc ion binding activity. Predicted to be involved in cholinergic synaptic transmission and positive regulation of neuromuscular synaptic transmission. Predicted to be active in neuromuscular junction and plasma membrane. Is expressed in adult head. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 11 and fetal akinesia deformation sequence syndrome 2. Orthologous to human RAPSN (receptor associated protein of the synapse). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG1909 in Genome Data Viewer
Location:
102C6-102C6; 4-0 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (583108..589348)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (603734..609974)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit Neighboring gene ephrin Neighboring gene long non-coding RNA:CR45199 Neighboring gene onecut

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential activity of EWG transcription factor isoforms identifies a subset of differentially regulated genes important for synaptic growth regulation. Haussmann IU, et al. Dev Biol, 2010 Dec 15. PMID 20854801
  2. HP1a recruitment to promoters is independent of H3K9 methylation in Drosophila melanogaster. Figueiredo ML, et al. PLoS Genet, 2012. PMID 23166515, Free PMC Article
  3. A presynaptic ENaC channel drives homeostatic plasticity. Younger MA, et al. Neuron, 2013 Sep 18. PMID 23973209, Free PMC Article
  4. dTcf/Pangolin suppresses growth and tumor formation in Drosophila. Song S, et al. Proc Natl Acad Sci U S A, 2019 Jul 9. PMID 31235567, Free PMC Article
  5. Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Chintapalli VR, et al. Nat Genet, 2007 Jun. PMID 17534367

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 586587-586659 mobile_element_type = transposon:INE-1{}6119

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acetylcholine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetylcholine receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables acetylcholine receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-membrane adaptor activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic transmission, cholinergic ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1909-PA
CG1909-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    583108..589348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143671.3 → NP_651928.1  uncharacterized protein Dmel_CG1909, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651928.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Y8
    Related
    FBpp0088148
    Conserved Domains (3) summary
    sd00006
    Location:94 → 122
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:249 → 322
    TPR_12; Tetratricopeptide repeat
    cl24038
    Location:89 → 168
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family

  2. NM_166773.2 → NP_726586.1  uncharacterized protein Dmel_CG1909, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Y8
    Related
    FBpp0088149
    Conserved Domains (3) summary
    sd00006
    Location:94 → 122
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:249 → 322
    TPR_12; Tetratricopeptide repeat
    cl24038
    Location:89 → 168
    SNAP; Soluble N-ethylmaleimide-sensitive factor (NSF) Attachment Protein family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K4Y8 Q7K4Y8

Gene LinkOut

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