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RunxA Runt related A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 4379817, updated on 9-Dec-2024

Summary

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Official Symbol
RunxAprovided by FlyBase
Official Full Name
Runt related Aprovided by FlyBase
Primary source
FLYBASE:FBgn0083981
Locus tag
Dmel_CG34145
See related
AllianceGenome:FB:FBgn0083981
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1379; CG15453; CG34145; Dmel\CG34145; RunXA; RUNXA
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Predicted to be located in nucleus. Is expressed in circular visceral muscle fiber and visceral muscle primordium. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See RunxA in Genome Data Viewer
Location:
19D3-19E1; 1-65 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20590252..20623773, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20461279..20494800, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Runt related B Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45466 Neighboring gene Cytochrome P450 6v1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms. Rennert J, et al. BMC Evol Biol, 2003 Mar 24. PMID 12659662, Free PMC Article
  2. Conserved cluster organization of insect Runx genes. Bao R, et al. Dev Genes Evol, 2008 Oct. PMID 18758811
  3. Evolutionary origin and genomic organisation of runt-domain containing genes in arthropods. Duncan EJ, et al. BMC Genomics, 2008 Nov 25. PMID 19032778, Free PMC Article
  4. Interactions and Feedbacks in E-Cadherin Transcriptional Regulation. Ramirez Moreno M, et al. Front Cell Dev Biol, 2021. PMID 34262912, Free PMC Article
  5. Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity. Guan W, et al. Cell Rep, 2022 Jun 28. PMID 35767953, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c20615191-20614832 mobile_element_type = transposon:INE-1{}5471

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
runt related A
Names
CG34145-PB
CG34145-PC
CG34145-PD
RunxA-PB
RunxA-PC
RunxA-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    20590252..20623773 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042820.3 → NP_001036285.2  runt related A, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036285.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KHQ3
    Conserved Domains (1) summary
    pfam00853
    Location:92 → 217
    Runt; Runt domain

  2. NM_134556.2 → NP_608400.2  runt related A, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_608400.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    R9PY33
    Conserved Domains (1) summary
    pfam00853
    Location:92 → 217
    Runt; Runt domain

  3. NM_001272818.1 → NP_001259747.1  runt related A, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259747.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PI08
    Conserved Domains (1) summary
    pfam00853
    Location:95 → 216
    Runt; Runt domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI08 M9PI08
Q0KHQ3 Q0KHQ3
R9PY33 R9PY33

Gene LinkOut

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