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CaMKI Calcium/calmodulin-dependent protein kinase I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43792, updated on 4-Jan-2025

Summary

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Official Symbol
CaMKIprovided by FlyBase
Official Full Name
Calcium/calmodulin-dependent protein kinase Iprovided by FlyBase
Primary source
FLYBASE:FBgn0016126
Locus tag
Dmel_CG1495
See related
AllianceGenome:FB:FBgn0016126
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Calcium/calmodulin-dependent protein kinase; CamK1; CaMK1; camKI; caMKI; CamKI; CAMKI; CG1495; dCKI; Dmel\CG1495
Summary
Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in adult head and eye. Orthologous to several human genes including CAMK1D (calcium/calmodulin dependent protein kinase ID). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CaMKI in Genome Data Viewer
Location:
102C1-102C1; 4-0 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (445504..453947)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (466130..474573)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44024 Neighboring gene legless Neighboring gene antisense RNA:CR45126 Neighboring gene TBP-associated factor 3 Neighboring gene uncharacterized protein Neighboring gene asator

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Immunochemical localization of calcium/calmodulin-dependent protein kinase I. Picciotto MR, et al. Synapse, 1995 May. PMID 7624832
  2. Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism. Clapperton JA, et al. Biochemistry, 2002 Dec 17. PMID 12475216
  3. An in vivo strategy for knockdown of circular RNAs. Pamudurti NR, et al. Cell Discov, 2020. PMID 32818061, Free PMC Article
  4. Social Context Enhances Hormonal Modulation of Pheromone Detection in Drosophila. Sethi S, et al. Curr Biol, 2019 Nov 18. PMID 31679932, Free PMC Article
  5. From fruitless to sex: On the generation and diversification of an innate behavior. Peng Q, et al. Genes Brain Behav, 2021 Nov. PMID 34672079

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of extensive electrostatic and hydrophobic contacts between calmodulin (CaM) and the CaM-binding domain peptide allows a detailed analysis of the structural basis of the kinase activation process.
    Title: Structure of the complex of calmodulin with the target sequence of calmodulin-dependent protein kinase I: studies of the kinase activation mechanism.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: 448779-449248 mobile_element_type = transposon:INE-1{}5914
  • Loc: 450697-451157 mobile_element_type = transposon:INE-1{}5918

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Calcium/calmodulin-dependent protein kinase I
Names
CG1495-PA
CG1495-PB
CG1495-PG
CG1495-PH
CG1495-PI
CaMKI-PA
CaMKI-PB
CaMKI-PG
CaMKI-PH
CaMKI-PI
calmodulin-dependent kinase
NP_524622.1
NP_726569.1
NP_726570.1
NP_726571.2
NP_726574.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    445504..453947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079883.3 → NP_524622.1  Calcium/calmodulin-dependent protein kinase I, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524622.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMV3
    Related
    FBpp0088134
    Conserved Domains (2) summary
    smart00220
    Location:31 → 302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14083
    Location:27 → 301
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

  2. NM_166764.2 → NP_726574.1  Calcium/calmodulin-dependent protein kinase I, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726574.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KIF7, Q8IGW6
    Related
    FBpp0088132
    Conserved Domains (2) summary
    smart00220
    Location:1 → 181
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1 → 180
    PKc_like; Protein Kinases, catalytic domain

  3. NM_166761.2 → NP_726571.2  Calcium/calmodulin-dependent protein kinase I, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726571.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V110
    Conserved Domains (2) summary
    smart00220
    Location:31 → 287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14083
    Location:27 → 286
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

  4. NM_166760.2 → NP_726570.1  Calcium/calmodulin-dependent protein kinase I, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMV3
    Related
    FBpp0088138
    Conserved Domains (2) summary
    smart00220
    Location:31 → 302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14083
    Location:27 → 301
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I

  5. NM_166759.2 → NP_726569.1  Calcium/calmodulin-dependent protein kinase I, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_726569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMV3
    Related
    FBpp0088136
    Conserved Domains (2) summary
    smart00220
    Location:31 → 302
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14083
    Location:27 → 301
    STKc_CaMKI; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4V110 A4V110
Q0KIF7 Q0KIF7
Q7JMV3 Q7JMV3
Q86P88 Q86P88
Q8IGW6 Q8IGW6

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