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RhoGAP100F Rho GTPase activating protein at 100F [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43758, updated on 4-Jan-2025

Summary

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Official Symbol
RhoGAP100Fprovided by FlyBase
Official Full Name
Rho GTPase activating protein at 100Fprovided by FlyBase
Primary source
FLYBASE:FBgn0039883
Locus tag
Dmel_CG1976
See related
AllianceGenome:FB:FBgn0039883
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1976; CG1976; Dmel\CG1976; DSyd; dsyd-1; dSyd-1; Dsyd-1; DSyd-1; DSyd1; RHOGAP100F; syd-1; Syd-1; syd1; Syd1
Summary
Predicted to enable GTPase activator activity. Involved in several processes, including cytoskeletal matrix organization at active zone; maintenance of presynaptic active zone structure; and nervous system development. Located in presynaptic active zone. Is active in neuromuscular junction and presynaptic active zone cytoplasmic component. Is expressed in several structures, including adult brain; adult mushroom body; embryonic/larval neuromuscular junction; mushroom body calyx; and organism subdivision. Orthologous to several human genes including SYDE2 (synapse defective Rho GTPase homolog 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See RhoGAP100F in Genome Data Viewer
Location:
100D2-100D3; 3-102 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31812609..31846570)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27638331..27672292)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Riboflavin transporter Neighboring gene Ferrochelatase Neighboring gene hephaestus Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45556

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An antagonism between Spinophilin and Syd-1 operates upstream of memory-promoting presynaptic long-term plasticity. Ramesh N, et al. Elife, 2023 Sep 28. PMID 37767892, Free PMC Article
  2. Aversive teaching signals from individual dopamine neurons in larval Drosophila show qualitative differences in their temporal "fingerprint". Weiglein A, et al. J Comp Neurol, 2021 May 1. PMID 32965036
  3. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Gao R, et al. Science, 2019 Jan 18. PMID 30655415, Free PMC Article
  4. Aversive Learning and Appetitive Motivation Toggle Feed-Forward Inhibition in the Drosophila Mushroom Body. Perisse E, et al. Neuron, 2016 Jun 1. PMID 27210550, Free PMC Article
  5. Structural and functional plasticity of the cytoplasmic active zone. Sigrist SJ, et al. Curr Opin Neurobiol, 2011 Feb. PMID 20832284

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our live data support a "serial synapse formation" model, where at any time point only 1-2 "synaptogenic" filopodia suppress the synaptic competence of other filopodia through competition for synaptic seeding factors. Loss of the synaptic seeding factors Syd-1 and Liprin-alpha leads to a loss of this suppression, filopodial destabilization, and reduced synapse formation.
    Title: Serial Synapse Formation through Filopodial Competition for Synaptic Seeding Factors.
  2. The Syd-1/liprin-alpha/PP2A pathway stabilizes the active zone in synaptic terminals.
    Title: Drosophila Syd-1, liprin-α, and protein phosphatase 2A B' subunit Wrd function in a linear pathway to prevent ectopic accumulation of synaptic materials in distal axons.
  3. cooperation between Syd-1 and Nrx-1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes
    Title: Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly.
  4. DSyd-1 might stall synaptic proteins other than DLiprin-, e.g., adhesion molecules, to regulate postsynaptic maturation in a trans-synaptic manner.
    Title: A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISM
Inferred from Sequence Model
more info
  
enables GTPase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in R7 cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in Rho protein signal transduction ISM
Inferred from Sequence Model
more info
  
involved_in activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in axon extension involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoskeletal matrix organization at active zone IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maintenance of presynaptic active zone structure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in presynaptic active zone organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in neuromuscular junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Rho GTPase activating protein at 100F
Names
CG1976-PB
CG1976-PC
CG1976-PD
CG1976-PE
CG1976-PF
CG1976-PH
CG1976-PI
CG1976-PJ
RhoGAP100F-PB
RhoGAP100F-PC
RhoGAP100F-PD
RhoGAP100F-PE
RhoGAP100F-PF
RhoGAP100F-PH
RhoGAP100F-PI
RhoGAP100F-PJ
synapse defective-1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31812609..31846570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170315.3 → NP_001163786.1  Rho GTPase activating protein at 100F, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163786.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C3KGQ2, E1JJ30, E1JJ31, Q8SWW5, Q9V9S7
    Conserved Domains (3) summary
    cd00030
    Location:804 → 905
    C2; C2 domain
    cd00992
    Location:177 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:946 → 1144
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  2. NM_001300700.1 → NP_001287629.1  Rho GTPase activating protein at 100F, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287629.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LJ24
    Conserved Domains (3) summary
    cd00030
    Location:804 → 905
    C2; C2 domain
    cd00992
    Location:177 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:946 → 1144
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  3. NM_001260468.2 → NP_001247397.2  Rho GTPase activating protein at 100F, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247397.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7S3
    Conserved Domains (3) summary
    cd00030
    Location:804 → 905
    C2; C2 domain
    cd00992
    Location:177 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:946 → 1144
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  4. NM_001170314.2 → NP_001163785.1  Rho GTPase activating protein at 100F, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163785.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I0C0N0
    Conserved Domains (3) summary
    cd00030
    Location:804 → 905
    C2; C2 domain
    cd00992
    Location:177 → 260
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:946 → 1144
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  5. NM_001260467.2 → NP_001247396.1  Rho GTPase activating protein at 100F, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247396.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7G3
    Conserved Domains (3) summary
    cd00030
    Location:791 → 892
    C2; C2 domain
    cd00992
    Location:166 → 249
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:933 → 1131
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  6. NM_001260465.1 → NP_001247394.1  Rho GTPase activating protein at 100F, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247394.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6W5
    Conserved Domains (3) summary
    cd00030
    Location:794 → 895
    C2; C2 domain
    cd00992
    Location:166 → 249
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:936 → 1134
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  7. NM_001260466.1 → NP_001247395.1  Rho GTPase activating protein at 100F, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247395.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K813
    Conserved Domains (3) summary
    cd00030
    Location:793 → 894
    C2; C2 domain
    cd00992
    Location:166 → 249
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:935 → 1133
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...

  8. NM_143645.2 → NP_651902.2  Rho GTPase activating protein at 100F, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651902.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9S7
    Conserved Domains (3) summary
    cd00030
    Location:793 → 894
    C2; C2 domain
    cd00992
    Location:166 → 249
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04379
    Location:935 → 1133
    RhoGAP_SYD1; RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6W5 A0A0B4K6W5
A0A0B4K7G3 A0A0B4K7G3
A0A0B4K7S3 A0A0B4K7S3
A0A0B4K813 A0A0B4K813
A0A0B4LJ24 A0A0B4LJ24
Q9V9S7.2 Q9V9S7

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