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FeCH Ferrochelatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43757, updated on 9-Dec-2024

Summary

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Official Symbol
FeCHprovided by FlyBase
Official Full Name
Ferrochelataseprovided by FlyBase
Primary source
FLYBASE:FBgn0266268
Locus tag
Dmel_CG2098
See related
AllianceGenome:FB:FBgn0266268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2098; Dmel\CG2098; ferrochelatase
Summary
Enables ferrochelatase activity. Predicted to be involved in heme biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See FeCH in Genome Data Viewer
Location:
100D2-100D2; 3-102 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31810460..31812296, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27636182..27638018, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein at 100F Neighboring gene uncharacterized protein Neighboring gene Riboflavin transporter Neighboring gene hephaestus Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification, crystallization and preliminary X-ray analysis of Drosophila melanogaster ferrochelatase. Wang KF, et al. Acta Crystallogr D Biol Crystallogr, 1999 Jun. PMID 10329785
  2. Evidence that the fourth ligand to the [2Fe-2S] cluster in animal ferrochelatase is a cysteine. Characterization of the enzyme from Drosophila melanogaster. Sellers VM, et al. J Biol Chem, 1998 Aug 28. PMID 9712849
  3. Spatial and temporal control of gene manipulation in Drosophila via drug-activated Cas9 nucleases. Huynh N, et al. Insect Biochem Mol Biol, 2020 May. PMID 32105778
  4. A Syd-1 homologue regulates pre- and postsynaptic maturation in Drosophila. Owald D, et al. J Cell Biol, 2010 Feb 22. PMID 20176924, Free PMC Article
  5. A Drosophila CRISPR/Cas9 Toolkit for Conditionally Manipulating Gene Expression in the Prothoracic Gland as a Test Case for Polytene Tissues. Huynh N, et al. G3 (Bethesda), 2018 Nov 6. PMID 30213867, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ferrochelatase
Names
CG2098-PA
CG2098-PB
CG2098-PC
FeCH-PA
FeCH-PB
FeCH-PC
NP_524613.1
NP_733458.1
NP_733459.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31810460..31812296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079874.3 → NP_524613.1  ferrochelatase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524613.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O76533, Q8IGA4, Q8IH67, Q8IMF9, Q95U82, Q9V9S8
    Related
    FBpp0085208
    Conserved Domains (3) summary
    cd00419
    Location:195 → 332
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:29 → 190
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:29 → 349
    Ferrochelatase; Ferrochelatase

  2. NM_170579.3 → NP_733458.1  ferrochelatase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733458.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9S8
    Related
    FBpp0085209
    Conserved Domains (3) summary
    cd00419
    Location:195 → 280
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    cd03411
    Location:29 → 190
    Ferrochelatase_N; Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:29 → 280
    Ferrochelatase; Ferrochelatase

  3. NM_170580.3 → NP_733459.2  ferrochelatase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733459.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9S8
    Related
    FBpp0085210
    Conserved Domains (2) summary
    cd00419
    Location:37 → 174
    Ferrochelatase_C; Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ...
    pfam00762
    Location:21 → 191
    Ferrochelatase; Ferrochelatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9S8.1 Q9V9S8

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