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nero nero [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43740, updated on 9-Dec-2024

Summary

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Official Symbol
neroprovided by FlyBase
Official Full Name
neroprovided by FlyBase
Primary source
FLYBASE:FBgn0261479
Locus tag
Dmel_CG2245
See related
AllianceGenome:FB:FBgn0261479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2245; Dmel\CG2245; DOHH; l(3)s1921
Summary
Enables deoxyhypusine monooxygenase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Located in endoplasmic reticulum membrane. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut; embryonic/larval midgut primordium; and mesoderm. Orthologous to human DOHH (deoxyhypusine hydroxylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See nero in Genome Data Viewer
Location:
100D2-100D2; 3-102 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31746445..31747558, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27572167..27573280, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Tubulin binding cofactor A Neighboring gene uncharacterized protein Neighboring gene abnormal wing discs Neighboring gene uncharacterized protein Neighboring gene salty dog Neighboring gene mir-1014 stem loop

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila deoxyhypusine hydroxylase homologue nero and its target eIF5A are required for cell growth and the regulation of autophagy. Patel PH, et al. J Cell Biol, 2009 Jun 29. PMID 19546244, Free PMC Article
  2. Spatiotemporal patterning of polyamines in Drosophila development. Burnette M, et al. Amino Acids, 2015 Dec. PMID 26386564
  3. Identification of circadian-clock-regulated enhancers and genes of Drosophila melanogaster by transposon mobilization and luciferase reporting of cyclical gene expression. Stempfl T, et al. Genetics, 2002 Feb. PMID 11861563, Free PMC Article
  4. MicroRNA miR-308 regulates dMyc through a negative feedback loop in Drosophila. Daneshvar K, et al. Biol Open, 2013 Jan 15. PMID 23336071, Free PMC Article
  5. Novel protein domains and repeats in Drosophila melanogaster: insights into structure, function, and evolution. Ponting CP, et al. Genome Res, 2001 Dec. PMID 11731489

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables deoxyhypusine monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyhypusine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyhypusine monooxygenase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables deoxyhypusine monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in peptidyl-lysine modification to peptidyl-hypusine IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-lysine modification to peptidyl-hypusine IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in peptidyl-lysine modification to peptidyl-hypusine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nero
Names
CG2245-PA
deoxyhypusine hydroxylase
lethal (3) s1921
nero-PA
NP_651887.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31746445..31747558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143630.2 → NP_651887.1  nero [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651887.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V9U4
    Related
    FBpp0085222
    Conserved Domains (3) summary
    smart00567
    Location:85 → 114
    EZ_HEAT; E-Z type HEAT repeats
    pfam13646
    Location:43 → 126
    HEAT_2; HEAT repeats
    sd00044
    Location:39 → 67
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9U4.1 Q9V9U4

Gene LinkOut

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