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gammaCOP Coat Protein (coatomer) gamma [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43717, updated on 9-Dec-2024

Summary

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Official Symbol
gammaCOPprovided by FlyBase
Official Full Name
Coat Protein (coatomer) gammaprovided by FlyBase
Primary source
FLYBASE:FBgn0028968
Locus tag
Dmel_CG1528
See related
AllianceGenome:FB:FBgn0028968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0573/02; 573.02; anon-WO0118547.334; CG1528; copg; COPIgamma; Dmel\CG1528; gamma-cop; gamma-COP; Gamma-COP; gammaCop; l(3)S057302; l(3)S057302b
Summary
Predicted to enable structural molecule activity. Involved in several processes, including chitin-based embryonic cuticle biosynthetic process; larval salivary gland morphogenesis; and open tracheal system development. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in adult brain; adult head; meiotic primary spermatocyte; onion stage spermatid; and primary spermatocyte. Orthologous to human COPG1 (COPI coat complex subunit gamma 1) and COPG2 (COPI coat complex subunit gamma 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See gammaCOP in Genome Data Viewer
Location:
100C6-100C6; 3-102 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31572143..31575707)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27397865..27401429)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46120 Neighboring gene long non-coding RNA:CR46119 Neighboring gene pygopus Neighboring gene rough deal

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations of γCOP Gene Disturb Drosophila melanogaster Innate Immune Response to Pseudomonas aeruginosa. Chifiriuc MC, et al. Int J Mol Sci, 2022 Jun 10. PMID 35742941, Free PMC Article
  2. Effects of Pseudomonas aeruginosa infection on the expression profile of transient receptor potential-like (TRPL) gene from Drosophila melanogaster. Mihalache (Radu) MR, et al. Roum Arch Microbiol Immunol, 2016 Jan-Jun. PMID 29616531
  3. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate, insect and plant evolution. Hahn Y, et al. FEBS Lett, 2000 Sep 29. PMID 11018518
  4. gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster. Grieder NC, et al. PLoS One, 2008 Sep 19. PMID 18802472, Free PMC Article
  5. In vivo assembly and trafficking of olfactory Ionotropic Receptors. Abuin L, et al. BMC Biol, 2019 Apr 17. PMID 30995910, Free PMC Article

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster
    Title: gammaCOP is required for apical protein secretion and epithelial morphogenesis in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in branch fusion, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chitin-based embryonic cuticle biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in larval salivary gland morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle transport along microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of tube diameter, open tracheal system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in acroblast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cis-Golgi network IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
coat protein (coatomer) gamma
Names
CG1528-PA
CG1528-PB
CG1528-PC
CG1528-PD
COPI gamma subunit
gamma-coatomer protein
gammaCOP-PA
gammaCOP-PB
gammaCOP-PC
gammaCOP-PD
gammaCop
lethal (3) S057302b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31572143..31575707
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170553.2 → NP_733432.1  coat protein (coatomer) gamma, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733432.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1JJ29, Q8I0G5, Q8MYW4, Q9U677, Q9V9W9
    UniProtKB/TrEMBL
    G4LU37
    Related
    FBpp0085155
    Conserved Domains (4) summary
    COG5240
    Location:19 → 882
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    pfam08752
    Location:625 → 766
    COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
    pfam16381
    Location:768 → 882
    Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
    sd00044
    Location:407 → 432
    HEAT; HEAT repeat [structural motif]

  2. NM_079869.3 → NP_524608.1  coat protein (coatomer) gamma, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524608.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU37
    Related
    FBpp0085154
    Conserved Domains (4) summary
    COG5240
    Location:3 → 878
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    pfam08752
    Location:621 → 762
    COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
    pfam16381
    Location:764 → 878
    Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
    sd00044
    Location:403 → 428
    HEAT; HEAT repeat [structural motif]

  3. NM_001170313.1 → NP_001163784.1  coat protein (coatomer) gamma, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163784.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G4LU37
    Conserved Domains (4) summary
    COG5240
    Location:11 → 877
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    pfam08752
    Location:620 → 761
    COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
    pfam16381
    Location:763 → 877
    Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
    sd00044
    Location:402 → 427
    HEAT; HEAT repeat [structural motif]

  4. NM_001276216.1 → NP_001263145.1  coat protein (coatomer) gamma, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263145.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHL2, G4LU37
    Conserved Domains (4) summary
    COG5240
    Location:11 → 877
    SEC21; Vesicle coat complex COPI, gamma subunit [Intracellular trafficking and secretion]
    pfam08752
    Location:620 → 761
    COP-gamma_platf; Coatomer gamma subunit appendage platform subdomain
    pfam16381
    Location:763 → 877
    Coatomer_g_Cpla; Coatomer subunit gamma-1 C-terminal appendage platform
    sd00044
    Location:402 → 427
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHL2 A0A0B4KHL2
Q2VA12 Q2VA12
Q8I0G5.1 Q8I0G5

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